IBB UAB

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Dr. I. Roig : ATR is required to complete meiotic recombination in mice

Dr. I. Roig : ATR is required to complete meiotic recombination in mice

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  Precise execution of recombination during meiosis is essential for forming chromosomally-balanced gametes. Meiotic recombination initiates with the formation and resection of DNA double-strand breaks (DSBs). Cellular responses to meiotic DSBs are critical for efficient repair and quality control, but molecular features of these remain poorly understood, particularly in mammals. Here we report that the DNA damage response protein kinase ATR is crucial for meiotic recombination and completion of meiotic prophase in mice. Using a hypomorphic Atr mutation and pharmacological inhibition of ATR in vivo and in cultured spermatocytes, we show that ATR, through its effector kinase CHK1, promotes efficient RAD51 and DMC1 assembly at RPA-coated resected DSB sites and establishment of interh...
Nanoligent, the spin off created by the Directors of Units 1 and 18 of NANBIOSIS, awarded for the best company in Health Sciences given by the law firm RCD

Nanoligent, the spin off created by the Directors of Units 1 and 18 of NANBIOSIS, awarded for the best company in Health Sciences given by the law firm RCD

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NANOLIGENT is awarded for the best company in Health Sciences  Price given by the law firm RCD. The XXIII Investment Forum of ACCIÓ 2018 was celebrated last June 20th  with the aim of connecting with the world of private investment.  ACCIÓ, Company Competitiveness Agency, had previously published a catalog of startups with the most potential startups in Catalonia, projects selected from more than 100 candidatures were presented for the 2018 Investment Forum of ACTION. The 50 companies in this catalog stand out due to their differential nature and innovative value, due to their social impact and the involvement of the entrepreneurial team. They are companies operating in key sectors for the economy of the future such as life and health sciences, ICT and other crucial cutting-edge technolog
Self-assembling toxin-based nanoparticles as self-delivered antitumoral drugs

Self-assembling toxin-based nanoparticles as self-delivered antitumoral drugs

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Abstract Loading capacity and drug leakage from vehicles during circulation in blood is a major concern when developing nanoparticle-based cell-targeted cytotoxics. To circumvent this potential issue it would be convenient the engineering of drugs as self-delivered nanoscale entities, devoid of any heterologous carriers. In this context, we have here engineered potent protein toxins, namely segments of the diphtheria toxin and the Pseudomonas aeruginosa exotoxin as self-assembling, self-delivered therapeutic materials targeted to CXCR4+ cancer stem cells. The systemic administration of both nanostructured drugs in a colorectal cancer xenograft mouse model promotes efficient and specific local destruction of target tumor tissues and a significant reduction of the tumor volume. This o...
Selective CXCR4+ Cancer Cell Targeting and Potent Antineoplastic Effect by a Nanostructured Version of Recombinant Ricin

Selective CXCR4+ Cancer Cell Targeting and Potent Antineoplastic Effect by a Nanostructured Version of Recombinant Ricin

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  Abstract Under the unmet need of efficient tumor‐targeting drugs for oncology, a recombinant version of the plant toxin ricin (the modular protein T22‐mRTA‐H6) is engineered to self‐assemble as protein‐only, CXCR4‐targeted nanoparticles. The soluble version of the construct self‐organizes as regular 11 nm planar entities that are highly cytotoxic in cultured CXCR4+ cancer cells upon short time exposure, with a determined IC50 in the nanomolar order of magnitude. The chemical inhibition of CXCR4 binding sites in exposed cells results in a dramatic reduction of the cytotoxic potency, proving the receptor‐dependent mechanism of cytotoxicity. The insoluble version of T22‐mRTA‐H6 is, contrarily, moderately active, indicating that free, nanostructured protein is
Release of targeted protein nanoparticles from functional bacterial amyloids: A death star-like approach

Release of targeted protein nanoparticles from functional bacterial amyloids: A death star-like approach

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Abstract Sustained release of drug delivery systems (DDS) has the capacity to increase cancer treatment efficiency in terms of drug dosage reduction and subsequent decrease of deleterious side effects. In this regard, many biomaterials are being investigated but none offers morphometric and functional plasticity and versatility comparable to protein-based nanoparticles (pNPs). Here we describe a new DDS by which pNPs are fabricated as bacterial inclusion bodies (IB), that can be easily isolated, subcutaneously injected and used as reservoirs for the sustained release of targeted pNPs. Our approach combines the high performance of pNP, regarding specific cell targeting and biodistribution with the IB supramolecular organization, stability and cost effectiveness. This renders a platform a
Switching cell penetrating and CXCR4-binding activities of nanoscale-organized arginine-rich peptides

Switching cell penetrating and CXCR4-binding activities of nanoscale-organized arginine-rich peptides

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Abstract Arginine-rich protein motifs have been described as potent cell-penetrating peptides (CPPs) but also as rather specific ligands of the cell surface chemokine receptor CXCR4, involved in the infection by the human immunodeficiency virus (HIV).  Polyarginines are commonly used to functionalize nanoscale vehicles for gene therapy and drug delivery, aimed to enhance cell penetrability of the therapeutic cargo. However, under which conditions these peptides do act as either unspecific or specific ligands is unknown. We have here explored the cell penetrability of differently charged polyarginines in two alternative presentations, namely as unassembled fusion proteins or assembled in multimeric protein nanoparticles. By this, we have observed that arginine-rich peptides switch bet
Dissenyen bioestructures mínimes per crear nanomaterials

Dissenyen bioestructures mínimes per crear nanomaterials

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Investigadors de l’IBB-UAB han fabricat 4 molècules de només 7 aminoàcids amb capacitat d’autoassemblar-se per formar nanomaterials per a biomedicina i nanotecnologia de manera més ràpida i econòmica, inspirant-se en el tipus d’assemblatge natural de les fibres amiloides. Amb els nous heptapèptids, els investigadors de l’IBB-UAB han demostrat que només amb 4  tipus d’aminoàcids diferents distribuïts de manera específica, i combinats sempre amb un  mateix cinquè tipus, és suficient per tenir el codi complert que permet formar fibres priòniques sintètiques.   Investigadors de l’Institut de Biotecnologia i de Biomedicina (IBB-UAB) han generat 4 pèptids -molècules més petites que les proteïnes- capaços d’autoassemblar-se de manera controlada per formar nanomaterials.
Creada una nova spin-off de la UAB per desenvolupar una nanomedicina per al tractament del càncer

Creada una nova spin-off de la UAB per desenvolupar una nanomedicina per al tractament del càncer

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Nanoligent, impulsada per investigadors de l'Institut de Biotecnologia i Biomedicina de la UAB i l'Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau, aspira a crear el primer fàrmac dissenyat per eliminar les cèl·lules mare metastàtiques. Investigadors de l'Institut de Biotecnologia i Biomedicina de la Universitat Autònoma de Barcelona, de l'Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau i del CIBER de Bioenginyeria, Biomaterials i Nanomedicina han desenvolupat una nanomedicina per al tractament de les metàstasis mitjançant l'eliminació selectiva de les cèl·lules mare tumorals. Es tracta d'un sistema basat en nanopartícules que transporten un fàrmac quimioterapèutic i l'alliberen dins les cèl·lules canceroses.   L'equip d'investigadors, liderat p
Identificat un nou mecanisme de regulació d’una SUMO E3 lligasa

Identificat un nou mecanisme de regulació d’una SUMO E3 lligasa

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Un estudi liderat pel Dr. David Reverter, investigador del IBB i del Departament de Bioquímica i Biologia Molecular de la UAB, i pel Dr. Jordi Torres-Rosell, del IRB-Lleida, han identificat un nou mecanisme de regulació d’una E3 SUMO lligasa essencial durant processos de reparació de trencaments del material genètic (DNA). El treball acaba de publicar-se a la revista EMBO Journal.   La integritat del nostre genoma està contínuament sota vigilància, ja que processos de trencament del DNA poden conduir a la mort cel·lular o a una proliferació cel·lular descontrolada i esdevenir cèl·lules canceroses. El nostre material genètic s’està contínuament copiant i moltes vegades apareixen trencaments o errors en les copies que s’han de corregir. Al llarg de l’evolució les nostres cèl·lules han dese