IBB UAB

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Activitats posposades

Activitats posposades

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Donades les indicacions de les autoritats sanitàries i polítiques, L’IBB ha decidit ajornar totes les activitats previstes fins a nou avís. Us anirem fent saber les noves dates. Gràcies per la comprensió.
En el marc dels actes del 50è aniversari de l’IBB hem organitzat un crida fotogràfica

En el marc dels actes del 50è aniversari de l’IBB hem organitzat un crida fotogràfica

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En el marc dels actes del 50è aniversari de l’IBB hem organitzat un crida fotogràfica sota el títol transversal de: La vida al laboratori S’accepten imatges en format digital, tant en blanc i negre com el color, sobre la vida i activitat dels laboratoris de l’Institut, des d’una visió artística o documental. Es poden fotografiar laboratoris, objectes, aparells, estris i material de recerca (sense mostrar marques), així com persones (en aquest cas, convé que el fotògraf tingui una cessió explícita dels drets de imatge –es pot trobar un model aquí-), que reflecteixin la quotidianitat de la recerca a l’Institut. També s’acceptaran imatges obtingudes per medi d’aparells analítics (microscòpia, blots, genòmica, etc), sempre que estiguin lliures de drets de còpia. Cada persona pot enviar fi
IBB 50 Aniversari

IBB 50 Aniversari

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Aquest any 2020 l’Institut de Biotecnologia i de Biomedicina (IBB) de la UAB, antic Institut de Biologia Fonamental (IBF), fa 50 anys. Per celebrar-ho, el centre organitza diverses activitats durant tot l’any. Amb el propòsit de posar en valor la recerca i la formació fetes al centre al llarg d’aquests anys s’ha organitzat un cicle de seminaris d’antics membres de l’IBB amb diversos perfils, de diferents generacions i amb trajectòries professionals ben diferents perquè ofereixin una visió àmplia de les sortides laborals un cop acabada la formació universitària reglada. Des de l’IBB s’espera que l’activitat, organitzada amb la col·laboració del Servei d’Ocupabilitat de la UAB i Alumni UAB, sigui una motivació extra per als actuals i futurs estudiants de la UAB a l’hora de visualitzar el
Dra. Aurora Ruiz-Herrera: “Chromosomal Differentiation in Genetically Isolated Populations of the Marsh-Specialist Crocidura suaveolens (Mammalia: Soricidae)”

Dra. Aurora Ruiz-Herrera: “Chromosomal Differentiation in Genetically Isolated Populations of the Marsh-Specialist Crocidura suaveolens (Mammalia: Soricidae)”

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Abstract The genus Crocidura represents a remarkable model for the study of chromosome evolution. This is the case of the lesser white-toothed shrew (Crocidura suaveolens), a representative of the Palearctic group. Although continuously distributed from Siberia to Central Europe, C. suaveolens is a rare, habitat-specialist species in the southwesternmost limit of its distributional range, in the Gulf of Cádiz (Iberian Peninsula). In this area, C. suaveolens is restricted to genetically isolated populations associated to the tidal marches of five rivers (Guadiana, Piedras, Odiel, Tinto and Guadalquivir). This particular distributional range provides a unique opportunity to investigate whether genetic differentiation and habitat specialization was accompanied by chromosomal variation.
Dra. Nerea Roher and Dr. A Villaverde: Nanostructured recombinant protein particles raise specific antibodies against the nodavirus NNV coat protein in sole

Dra. Nerea Roher and Dr. A Villaverde: Nanostructured recombinant protein particles raise specific antibodies against the nodavirus NNV coat protein in sole

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https://doi.org/10.1016/j.fsi.2020.02.029 Highlights We test a nanoparticle vaccine made of nodavirus RGNNV/SJNNV coat protein in sole. Oral and i.p. delivery routes were compared via antibody and gene expression data. Injection without adjuvant triggered a strong systemic specific antibody response. Oral intubation evoked mainly a mucosal immune response. Nanoparticle VNNV-CNP is immunogenic in S. senegalensis juveniles. Abstract Nervous necrosis virus (NNV) reassortant strains RGNNV/SJNNV have emerged as a potent threat to the Mediterranean marine aquaculture industry, causing viral encephalopathy and retinopathy (VER) in Senegalese sole (Solea senegalensis). In this study, a cheap and practical vaccine strategy using bacterial inclusion bodies made of the coat pr
Dr Salvador Ventura: Chemical Chaperones as Novel Drugs for Parkinson’s Disease

Dr Salvador Ventura: Chemical Chaperones as Novel Drugs for Parkinson’s Disease

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https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(20)30031-9 Highlights Orthogonal strategies such as drug repositioning, rational design, and high-throughput screening have identified molecules that target α‐synuclein (α-syn) aggregation, the central molecular event in Parkinson’s disease (PD). The anti-aggregation compounds under development target the complete spectrum of α-syn conformers through different mechanisms: monomer stabilization, prevention of dimer formation, stabilization or disruption of oligomers, avoidance of secondary nucleation, and dismantling of fibrils. The potential of particular molecules to halt neurodegeneration in PD is already being evaluated in clinical trials. If successful, they might benefit patients suffering from other α-synuclei
Dr. A. Villaverde: The Biological Potential Hidden in Inclusion Bodies

Dr. A. Villaverde: The Biological Potential Hidden in Inclusion Bodies

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  https://doi.org/10.3390/pharmaceutics12020157 (registering DOI) Abstract Inclusion bodies (IBs) are protein nanoclusters obtained during recombinant protein production processes, and several studies have demonstrated their potential as biomaterials for therapeutic protein delivery. Nevertheless, IBs have been, so far, exclusively sifted by their biological activity in vitro to be considered in further protein-based treatments in vivo. Matrix metalloproteinase-9 (MMP-9) protein, which has an important role facilitating the migration of immune cells, was used as model protein. The MMP-9 IBs were compared with their soluble counterpart and with MMP-9 encapsulated in polymeric-based micelles (PM) through ionic and covalent binding. The soluble MMP-9 and the MMP-9-ionic PM showed t
Dra. Neus Ferrer-Miralles: Aggregation-prone peptides modulate activity of bovine interferon gamma released from naturally occurring protein nanoparticles

Dra. Neus Ferrer-Miralles: Aggregation-prone peptides modulate activity of bovine interferon gamma released from naturally occurring protein nanoparticles

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https://www.sciencedirect.com/science/article/pii/S1871678419302134?dgcid=coauthor https://doi.org/10.1016/j.nbt.2020.02.001 Abstract Efficient protocols for the production of recombinant proteins are indispensable for the development of the biopharmaceutical sector. Accumulation of recombinant proteins in naturally-occurring protein aggregates is detrimental to biopharmaceutical development. In recent years, the view of protein aggregates has changed with the recognition that they are a valuable source of functional recombinant proteins. In this study, bovine interferon-gamma (rBoIFN-γ) was engineered to enhance the formation of protein aggregates, also known as protein nanoparticles (NPs), by the addition of aggregation-prone peptides (APPs) in the generally recognized as safe (GR