IBB UAB

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La convocatòria 2018 del Programa ICREA Acadèmia ha concedit 45 distincions, de les quals 12 són per a personal investigador de la UAB. L’acte de lliurament va tenir lloc dimarts 30 d’abril al Palau de la Generalitat.

La convocatòria 2018 del Programa ICREA Acadèmia ha concedit 45 distincions, de les quals 12 són per a personal investigador de la UAB. L’acte de lliurament va tenir lloc dimarts 30 d’abril al Palau de la Generalitat.

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La Institució Catalana de Recerca i Estudis Avançats (ICREA) va resoldre el mes de març passat la convocatòria 2018 del Programa ICREA Acadèmia, amb la concessió de 45 distincions amb l’objectiu d’impulsar i premiar l’excel·lència de la recerca dels professors de les universitats públiques de Catalunya, 12 d’elles per a investigadors i investigadores de la UAB. El proppassat dimarts 30 d'abril, al Palau de la Generalitat, va tenir lloc l’acte de lliurament de les distincions presidit per la consellera d’Empresa i Coneixement, Àngels Chacón i amb la presència del secretari d’Universitats i Recerca, Francesc Xavier Grau. Els ICREA Acadèmia de la UAB de la convocatòria 2018 són Margarita León Borja, del Departament de Ciència Política i Dret Públic i de l’Institut de Govern i Polítiques Pú
Dra. Aurora Ruíz: PRDM9 diversity at fine geographical scale reveals contrasting evolutionary patterns and functional constraints in natural populations of house mice

Dra. Aurora Ruíz: PRDM9 diversity at fine geographical scale reveals contrasting evolutionary patterns and functional constraints in natural populations of house mice

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PRDM9 diversity at fine geographical scale reveals contrasting evolutionary patterns and functional constraints in natural populations of house mice Vara C, Capilla L, Ferretti L, Ledda A, Sanchéz-Guillén RA, Gabriel SI, Albert-Lizandra G, Florit-Sabater B, Bello-Rodríguez J, Ventura J, Searle JB, Mathias ML, Ruiz-Herrera A Mol Biol Evol. 2019 Apr 19. pii: msz091. doi: 10.1093/molbev/msz091 https://academic.oup.com/mbe/advance-article/doi/10.1093/molbev/msz091/5475506 Abstract One of the major challenges in evolutionary biology is the identification of the genetic basis of postzygotic reproductive isolation. Given its pivotal role in this process, here we explore the drivers that may account for the evolutionary dynamics of the PRDM9 gene between continental and island systems of
Dr. S. Ventura: The fitness cost and benefit of phase‐separated protein deposits

Dr. S. Ventura: The fitness cost and benefit of phase‐separated protein deposits

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http://msb.embopress.org/content/15/4/e8075 Abstract Phase separation of soluble proteins into insoluble deposits is associated with numerous diseases. However, protein deposits can also function as membrane‐less compartments for many cellular processes. What are the fitness costs and benefits of forming such deposits in different conditions? Using a model protein that phase‐separates into deposits, we distinguish and quantify the fitness contribution due to the loss or gain of protein function and deposit formation in yeast. The environmental condition and the cellular demand for the protein function emerge as key determinants of fitness. Protein deposit formation can influence cell‐to‐cell variation in free protein abundance between
Èxit del concurs Elevator Pitch dels instituts de recerca de la UAB

Èxit del concurs Elevator Pitch dels instituts de recerca de la UAB

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https://youtu.be/LeeI9dT3QUQ     L’investigador Pablo Machuca de l’INc va ser el guanyador del concurs d’Elevator Pitch organitzat el passat dijous dia 14 de març pels instituts de la Universitat Autònoma de Barcelona, IBB, INc i ICTA-UAB. Jon Lerga de l’IBB va ser el segon classificat, seguit per Carlos Soto de l’INc. La iniciativa, adreçada als doctorands i investigadors postdoctorals d’aquests tres instituts propis de recerca de la UAB, convidava als participants a explicar la seva recerca  en només dos minuts d’una manera interessant, amena i, fins i tot, divertida. Per dur-ho a terme, la convocatòria els va oferir un curs gratuït impartit pel grup Big Van Ciència en què els van ensenyar tècniques per parlar de ciència en públic. El concurs, que va tenir lloc a l’hiverna
Dra. Aurora Ruiz: Per-Nucleus Crossover Covariation and Implications for Evolution

Dra. Aurora Ruiz: Per-Nucleus Crossover Covariation and Implications for Evolution

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  Crossing over is a nearly universal feature of sexual reproduction. Here, analysis of crossover numbers on a per-chromosome and per-nucleus basis reveals a fundamental, evolutionarily conserved feature of meiosis: within individual nuclei, crossover frequencies covary across different chromosomes. This effect results from per-nucleus covariation of chromosome axis lengths. Crossovers can promote evolutionary adaptation. However, the benefit of creating favorable new allelic combinations must outweigh the cost of disrupting existing favorable combinations. Covariation concomitantly increases the frequencies of gametes with especially high, or especially low numbers of crossovers, and thus might concomitantly enhance the benefits of crossing over while reducing its costs. A four-lo...
Dr. S . Ventura : Biasing the native α-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity

Dr. S . Ventura : Biasing the native α-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity

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https://www.sciencedirect.com/science/article/pii/S2213231718309789 AnitaCarijaabFranciscaPinheiroabJordiPujolsabInês C.BráscDiana FernandesLázarocCarloSantambrogiodRitaGrandoridTiago F.OuteirocefSusannaNavarroabSalvadorVentura Abstract The aggregation of α-synuclein (α-syn) into amyloid fibrils is a major pathological hallmark of Parkinson's disease (PD) and other synucleinopathies. The mechanisms underlying the structural transition of soluble and innocuous α-syn to aggregated neurotoxic forms remains largely unknown. The disordered nature of α-syn has hampered the use of structure-based protein engineering approaches to elucidate the molecular determinants of this transition. The recent 3D structure of a pathogenic α-syn fibril provides a template for this kind of studies. Th
Dr. A Barbadilla:  PopHumanScan: the online catalog of human genome adaptation

Dr. A Barbadilla: PopHumanScan: the online catalog of human genome adaptation

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https://academic.oup.com/nar/article/47/D1/D1080/5134333 Abstract Since the migrations that led humans to colonize Earth, our species has faced frequent adaptive challenges that have left signatures in the landscape of genetic variation and that we can identify in our today’s genomes. Here, we (i) perform an outlier approach on eight different population genetic statistics for 22 non-admixed human populations of the Phase III of the 1000 Genomes Project to detect selective sweeps at different historical ages, as well as events of recurrent positive selection in the human lineage; and (ii) create PopHumanScan, an online catalog that compiles and annotates all candidate regions under selection to facilitate their validation and thoroughly analysis. Well-known examples of human genetic
Identifiquen més de 800 noves regions del genoma que podrien ser rellevants en l’evolució humana

Identifiquen més de 800 noves regions del genoma que podrien ser rellevants en l’evolució humana

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Investigadors de la UAB han trobat evidències genètiques d'adaptacions a 2.859 regions del genoma, incloses algunes conegudes com les responsables de la tolerància a la llet o de l'adaptació a l’altitud. Les dades són fruit del projecte PopHumanScan, un catàleg de regions que mostren evidències de la selecció natural en el genoma humà. Un estudi del grup de recerca Bioinformàtica de la Diversitat Genòmica (IBB-UAB), publicat a la revista Nucleic Acids Research, incrementa en un 40% el total dels senyals de selecció natural en el genoma humà detectades fins ara. Els investigadors han aconseguit sumar un total de 873 noves regions del genoma humà com a fermes candidates d'haver estat el blanc de la selecció natural en algun moment des del sorgiment de la nostra espècie fins al presen
Dr. A. Villaverde: Protein-driven nanomedicines in oncotherapy

Dr. A. Villaverde: Protein-driven nanomedicines in oncotherapy

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Proteins are organic macromolecules essential in life but exploited, mainly in recombinant versions, as drugs or vaccine components, among other uses in industry or biomedicine. In oncology, individual proteins or supramolecular complexes have been tailored as small molecular weight drug carriers for passive or active tumor cell-targeted delivery, through the de novo design of appropriate drug stabilizing vehicles, or by generating constructs with different extents of mimesis of natural cell-targeted entities, such as viruses. In most of these approaches, a convenient nanoscale size is achieved through the oligomeric organization of the protein component in the drug conjugate. Among the different taken strategies, highly cytotoxic proteins such as microbial or plant toxins have been conven...