Dra. Aurora Ruiz-Herrera: Three-Dimensional Genomic Structure and Cohesin Occupancy Correlate with Transcriptional Activity during Spermatogenesis
ARTICLE| VOLUME 28, ISSUE 2, P352-367.E9, JULY 09, 2019
Covadonga Vara; Andreu Paytuví-Gallart ; Yasmina Cuartero ;Paul D. Waters; Marc A. Marti-Renom; Aurora Ruiz-Herrera
Open Access DOI: https://doi.org/10.1016/j.celrep.2019.06.037
https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30803-4
Summary
Mammalian gametogenesis involves dramatic and tightly regulated chromatin remodeling, whose regulatory pathways remain largely unexplored. Here, we generate a comprehensive high-resolution structural and functional atlas of mouse spermatogenesis by combining in situ chromosome conformation capture sequencing (Hi-C), RNA sequencing (RNA-seq), and chromatin immunopr