Author: Nati Infante

El passat 17 de març, el Rector de la UAB Francisco Javier Lafuente, vista la proposta de resolució del jurat, va atorgar el V Premi a l’Excel·lència Docent a Sònia Casillas. Aquest premi té per objectiu valorar l’activitat docent del professorat i impulsar la innovació i la millora constant de la docència universitària. Està orientat a identificar i valorar la trajectòria del professorat de la UAB que hagi destacat de forma remarcable en aquest àmbit. La Sònia Casillas va finalitzar el doctorat en Genètica a la UAB el 2008, sota la supervisió dels investigadors Antonio Barbadilla i Alfredo Ruiz. Posteriorment, es va dedicar uns anys a la gestió científica de projectes de transferència tecnològica i va realitzar una estada post-doctoral a la University of Washington. L’any 2011 ret

REVIEW article Front. Cell Dev. Biol., 23 February 2023Sec. Nuclear Organization and DynamicsVolume 11 - 2023 | https://doi.org/10.3389/fcell.2023.1127440 Meiosis is a specialized cell division that generates haploid gametes and is critical for successful sexual reproduction. During the extended meiotic prophase I, homologous chromosomes progressively pair, synapse and desynapse. These chromosomal dynamics are tightly integrated with meiotic recombination (MR), during which programmed DNA double-strand breaks (DSBs) are formed and subsequently repaired. Consequently, parental chromosome arms reciprocally exchange, ultimately ensuring accurate homolog segregation and genetic diversity in the offspring. Surveillance mechanisms carefully monitor the MR and homologous chromosome syn

Les investigadores Aurora Ruiz Herrera i Nerea Roher van assistir el passat 8 de març a la reunió anual de coordinadors i coordinadores de la Societat Catalana de Biologia (SCB), a la seu de la societat a l'Institut d’Estudis Catalans. De les 19 Seccions Temàtiques de la SCB, l’Aurora Ruiz Herrera en coordina la secció de Biologia Evolutiva, mentre que la Nerea Roher coordina la secció d’Aqüicultura.

https://doi.org/10.1021/acssuschemeng.2c06635 Hèctor López-Laguna, Ariana Rueda, Carlos Martínez-Torró, Lucía Sánchez-Alba, José Vicente Carratalá, Jan Atienza-Garriga, Eloi Parladé, Julieta M. Sánchez, Naroa Serna, Eric Voltà-Durán, Neus Ferrer-Miralles, David Reverter, Ramon Mangues, Antonio Villaverde*, Esther Vázquez*, and Ugutz Unzueta* Abstract Nanoscale protein materials show increasing applications in biotechnology and biomedicine, addressing catalysis, drug delivery, or tissue engineering. Although protein oligomerization is reachable through several engineering approaches, including the use of divalent cations for histidine-rich stretches, the effectiveness of cation-His binding is influenced by protein conformation, media composition, and chelating agents. Thus, lo

Int. J. Mol. Sci. 2022, 23(24), 15543; https://doi.org/10.3390/ijms232415543 This work was performed by the Nanobiotechnology group, from IBB/UAB and CIBER-BBN (group CB06/01/0014) Abstract Vaults are protein nanoparticles that are found in almost all eukaryotic cells but are absent in prokaryotic ones. Due to their properties (nanometric size, biodegradability, biocompatibility, and lack of immunogenicity), vaults show enormous potential as a bio-inspired, self-assembled drug-delivery system (DDS). Vault architecture is directed by self-assembly of the “major vault protein” (MVP), the main component of this nanoparticle. Recombinant expression (in different eukaryotic systems) of the MVP resulted in the formation of nanoparticles that were indistinguishable from native vault

Pharmaceutics 2023, 15(3), 727; https://doi.org/10.3390/pharmaceutics15030727 Abstract Despite advances in the development of targeted therapies for acute myeloid leukemia (AML), most patients relapse. For that reason, it is still necessary to develop novel therapies that improve treatment effectiveness and overcome drug resistance. We developed T22-PE24-H6, a protein nanoparticle that contains the exotoxin A from the bacterium Pseudomonas aeruginosa and is able to specifically deliver this cytotoxic domain to CXCR4+ leukemic cells. Next, we evaluated the selective delivery and antitumor activity of T22-PE24-H6 in CXCR4+ AML cell lines and BM samples from AML patients. Moreover, we assessed the in vivo antitumor effect of this nanotoxin in a disseminated mouse model generated fr