IBB UAB

Author: Nati Infante

Evolutive Immunology: “Nanoplastics are bioaccumulated in fish liver and muscle and cause DNA damage after a chronic exposure”

Evolutive Immunology: “Nanoplastics are bioaccumulated in fish liver and muscle and cause DNA damage after a chronic exposure”

News
Environmental Research: Available online 14 May 2022, 113433 https://doi.org/10.1016/j.envres.2022.113433 Abstract The extent of the widespread, planetary contamination by plastic waste is difficult to fully capture. Nanoplastics (NPs) are currently in the center of research concerning plastic litter, both for the analytical challenges they pose and for their potential to provoke hazardous effects in organisms. However, there are still many unanswered questions in this multidisciplinary field, with a crucial missing piece being the quantification of NPs in fish tissues after in vivo exposures. Another relevant question that is still greatly unexplored is how a chronic exposure to NPs will affect fish health. This study aims to provide answers to both of these relevant knowled...

The IBB wants to attract talent to apply for the Margarita Salas Postdoctoral Grants

Highlights
The Institut de Biotecnologia i de Biomedicina (IBB), of the Universitat Autònoma de Barcelona (UAB), is interested in receiving Margarita Salas Postdoctoral candidates. The IBB’s mission is to discover and accelerate the development and implementation of relevant clinical knowledge and science-based products to make it easier for patients to live longer and in better conditions (call opens ~June 1st 2022)
Com evoluciona el genoma de les espècies? El paper clau de l’estructura 3D de les cèl·lules germinals masculines

Com evoluciona el genoma de les espècies? El paper clau de l’estructura 3D de les cèl·lules germinals masculines

News
Un estudi liderat per la UAB i la Universitat de Kent mostra com l'estructura tridimensional del genoma de les cèl·lules germinals masculines està implicada en l'evolució dels genomes de les espècies. Publicat a Nature Communications i realitzat en espècies de rosegadors, mostra que els esdeveniments cromosòmics que ocorren durant la formació d'òvuls i espermatozoides tenen un impacte diferent en l'evolució del genoma i obre noves vies de recerca sobre l'origen genètic de l'estructura del genoma en tots els organismes. Tradicionalment, l'estudi de genomes de diferents espècies de mamífers ha mostrat que, tot i que totes les espècies tenen un catàleg molt similar de gens, aquests poden estar ordenats de manera diferent per a cada espècie, i poden activar-se i desactivar-se de divers
Genome Integrity and Instability: “Fragile, unfaithful and persistent Ys—on how meiosis can shape sex chromosome evolution”

Genome Integrity and Instability: “Fragile, unfaithful and persistent Ys—on how meiosis can shape sex chromosome evolution”

News
Ruiz-Herrera, A., Waters, P.D. Fragile, unfaithful and persistent Ys—on how meiosis can shape sex chromosome evolution. Heredity (2022). https://doi.org/10.1038/s41437-022-00532-2 Abstract Sex-linked inheritance is a stark exception to Mendel’s Laws of Heredity. Here we discuss how the evolution of heteromorphic sex chromosomes (mainly the Y) has been shaped by the intricacies of the meiotic programme. We propose that persistence of Y chromosomes in distantly related mammalian phylogroups can be explained in the context of pseudoautosomal region (PAR) size, meiotic pairing strategies, and the presence of Y-borne executioner genes that regulate meiotic sex chromosome inactivation. We hypothesise that variation in PAR size can be an important driver for the evolution of recombi
Protein Folding and Conformational Diseases: “The small aromatic compound SynuClean-D inhibits the aggregation and seeded polymerization of multiple α-synuclein strains”

Protein Folding and Conformational Diseases: “The small aromatic compound SynuClean-D inhibits the aggregation and seeded polymerization of multiple α-synuclein strains”

News
Available online 4 April 2022, 101902 https://doi.org/10.1016/j.jbc.2022.101902 Abstract Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, as well as the accumulation of intra-neuronal proteinaceous inclusions known as Lewy bodies and Lewy neurites. The major protein component of Lewy inclusions is the intrinsically disordered protein α-Synuclein (α-Syn), which can adopt diverse amyloid structures. Different conformational strains of α-Syn have been proposed to be related to the onset of distinct synucleinopathies; however, how specific amyloid fibrils cause distinctive pathological traits is not clear. Here, we generated three different α-Syn amyloid conformations at differe
Nanobiotechnology: “All-in-one biofabrication and loading of recombinant vaults in human cells”

Nanobiotechnology: “All-in-one biofabrication and loading of recombinant vaults in human cells”

News
Biofabrication, Volume 14, Number 2 https://iopscience.iop.org/journal/1758-5090 Abstract One of the most promising approaches in the drug delivery field is the use of naturally occurring self-assembling protein nanoparticles, such as virus-like particles, bacterial microcompartments or vault ribonucleoprotein particles as drug delivery systems (DDSs). Among them, eukaryotic vaults show a promising future due to their structural features, in vitro stability and non-immunogenicity. Recombinant vaults are routinely produced in insect cells and purified through several ultracentrifugations, both tedious and time-consuming processes. As an alternative, this work proposes a new approach and protocols for the production of recombinant vaults in human cells by transient gene...

SEMINARIS: “Role of Stem Cells in Regenerative Medicine and Cancer Biology”PhD THAMIL SELVEE RAMASAMY. 12:30 h.

Events
We will be receiving an international visit at the IBB, under an Erasmus+ mobility grant, from Thamil Selvee, Head of the Stem Cell Biology Laboratory at the Universiti Malaya in Malaysia. You can also have a look at her full CV here. She will be hosted by Esther Vázquez. The visit at the IBB and other institutions will take place during the 4th-8th of April 2022.  Benefiting from the occasion, Thamil will give us all a seminar at the Aula IBB on April 6th 12.30 pm on the topic: Role of Stem Cells in Regenerative Medicine and Cancer Biology.
Yeast Molecular Biology: “The toxic effects of yeast Ppz1 phosphatase are counteracted by subcellular relocalization mediated by its regulatory subunit Hal3”

Yeast Molecular Biology: “The toxic effects of yeast Ppz1 phosphatase are counteracted by subcellular relocalization mediated by its regulatory subunit Hal3”

News
Marcel Albacar,Diego Velázquez,Antonio Casamayor,Joaquín Ariño https://doi.org/10.1002/1873-3468.14330 Abstract Overexpression of Saccharomyces cerevisiae protein phosphatase Ppz1 strongly impairs cell growth. Ppz1 is negatively regulated by its subunit Hal3, and Hal3 overexpression fully counteracts the toxic effects derived from high levels of the phosphatase. We show that Ppz1 localizes at the plasma membrane, and that co-expression of Hal3 recruits Ppz1 to internal membranes (mostly vacuolar). This effect is not observed in a catalytically impaired mutant of Ppz1. Disruption of intracellular trafficking by deletion of the ESCRT-0 component VPS27 abolishes both Hal3-mediated relocalization of Ppz1 and normalization of cell growth, without affecting Ppz1