Author: Nati Infante
Micro-cromosomes: evidència genòmica de l’origen dels cromosomes dels vertebrats
Els micro-cromosomes són components essencials dels cromosomes dels vertebrats actuals, inclosos els mamífers, en què es van fusionar i reorganitzar per formar els cromosomes presents en les diferents espècies. Així ho ha demostrat un estudi internacional amb participació de la UAB que ha rastrejat el seu origen i destí en ocells, rèptils i mamífers i ha identificat estructures cromosòmiques presents en l’origen dels vertebrats fa, almenys, 500 milions d’anys. Els resultats de la recerca, publicada en la revista PNAS, suposen un gran avanç en l’estudi de l’origen i la funció de l’organització del genoma de les espècies.
Els micro-cromosomes són un tipus de cromosomes de mida molt petita, típics del genoma d’ocells, alguns rèptils i peixos, però absents en els mamífers actuals. Cons
PhasAGE International Conference: Phase transitions in aging and age-related diseases.
11-14 October (VIRTUAL CONFERENCE)
The conference program will explore the fundamental aspects ofphase separation in normal biological functions and in diseases
(e.g. neurodegenerative disorders).
The conference will bring together members of the PhasAGE consortium and external speakers showcasing high impact achievements in the field of phase transitions in aging and late-onset diseases.
The scientific programme includes a scientific symposium organized by the group of early stage researchers. Young researchers and junior postdocs will have access to a workshop in alternative careers in science. A workshop dedicated to biotech stakeholders will be organized to increase awareness about potential therapeutic strategies in the field of phase transitions.
Registrati
Research advances in a treatment for multiple system atrophy
An IBB project led by Salvador Ventura has been one of six selected by the Multiple System Atrophy Coalition in its research grant programme. The grant will allow researchers to advance in the study of molecules they have identified as being potential candidates for a treatment of multiple system atrophy. This neurodegenerative disease affects more than 30,000 people in Europe.
The Protein Folding and Conformational Diseases research group at the Institute of Biotechnology and Biomedicine (IBB), led by Salvador Ventura, professor of the Department of Biochemistry and Molecular Biology, has won one of the grants awarded annually by the Multiple System Atrophy Coalition, a prestigious international non-profit organisation that aims to improve the quality of life of people with ...
Nanobiotechnology: “Tolerability to non-endosomal, micron-scale cell penetration probed with magnetic particles”
Colloids and Surfaces B: Biointerfaces : Volume 208, December 2021, 112123
https://doi.org/10.1016/j.colsurfb.2021.112123
Abstract
The capability of HeLa cells to internalize large spherical microparticles has been evaluated by using inorganic, magnetic microparticles of 1 and 2.8 µm of diameter. In both absence but especially under the action of a magnet, both types of particles were uptaken, in absence of cytotoxicity, by a significant percentage of cells, in a non-endosomal process clearly favored by the magnetic field. The engulfed particles efficiently drive inside the cells chemically associated proteins such as GFP and human alpha-galactosidase A, without any apparent loss of protein functionalities. While 1 µm particles are completely engulfed, at least a fr
Soledad Carinelli i Silio Lima de Moura, guanyadors dels Premis Extraordinaris de Doctorat de la UAB
Els dos doctorands han fet la tesi amb Maria Isabel Pividori Gurgo, Catedràtica a la facultat de Ciències i investigadora al Institut de Biotecnologia i Biomedicina (IBB) de la UAB. A més, la tesi de De Moura ha estat codirigida per Maria Mercè Martí Ripoll, també investigadora al IBB. Degut a la pandèmia, la cerimònia de l’any passat i aquest any es celebraran les dues, conjuntament, el proper mes de novembre.
Els dos guardonats han estat premiats per les seves tesis doctorals: Carinelli amb la seva tesi “Biomarkers detection of global infectious diseases based on magnetic particles”, defensada originalment el setembre de 2019, i Lima de Moura amb “From preconcentration to rapid detection of exosomes as biomarkers in clinical diagnosis”, presentada el juliol de 2020.
La cer