Author: Nati Infante

El 4 d'octubre, entitats de la societat civil catalana, amb la participació de la UAB i la UB, van constituir una Comissió Independent per a la mediació, el diàleg i la conciliació. Ara, totes les universitats catalanes han donat suport a aquesta iniciativa. Totes les universitats catalanes donem suport a la iniciativa de creació d'una comissió independent de mediació, diàleg i conciliació promoguda pel Col·legi de l'Advocacia de Barcelona i altres entitats de la societat civil. Universitat de Barcelona, Universitat Autònoma de Barcelona, Universitat Politècnica de Catalunya, Universitat Pompeu Fabra, Universitat de Lleida, Universitat de Girona, Universitat Rovira i Virgili, Universitat Ramon Llull, Universitat Oberta de Catalunya, Universitat de Vic - Universitat Central de Catalunya

  Perfecting prediction of mutational impact on the aggregation propensity of the ALS-associated hnRNPA2 prion-like protein Cristina Batlle, María rosario Fernández, Valentín Iglesias, Salvador Ventura http://onlinelibrary.wiley.com/doi/10.1002/1873-3468.12698/full   Abstract  An increasing number of human proteins are being found to bear a prion-like domain (PrLD) driving the formation of membraneless compartments through liquid–liquid phase separation. Point mutations in these PrLDs promote the transition to an amyloid-like state. There has been much debate on whether this aberrant aggregation is caused by compositional or sequential changes. A recent extensive mutational study of the ALS-associated prion-like hnRNPA2 protein provides a framework to discriminate t

Ciudad, M.T., Sorvillo, N., van Alphen, F.P., Catalán, D., Meijer, A.B., Voorberg, J. and Jaraquemada, D. (2017), Analysis of the HLA-DR peptidome from human dendritic cells reveals high affinity repertoires and nonconventional pathways of peptide generation. Journal of Leukocyte Biology, 101: 15-27.  https://doi.org/10.1189/jlb.6HI0216-069R Abstract Dendritic cells (DCs) are the major professional APCs of the immune system; however, their MHC-II–associated peptide repertoires have been hard to analyze, mostly because of their scarce presence in blood and tissues. In vitro matured human monocyte-derived DCs (MoDCs) are widely used as professional APCs in experimental systems. In this work, we have applied mass spectrometry to identify the HLA-DR–associated self-peptide re

Corresponding author: Carme Roura-Mir, carme.roura@uab.cat. Diabetes 2016;65(8):2356–2366 https://doi.org/10.2337/db15-1350 Abstract Many studies have shown that human natural killer T (NKT) cells can promote immunity to pathogens, but their regulatory function is still being investigated. Invariant NKT (iNKT) cells have been shown to be effective in preventing type 1 diabetes in the NOD mouse model. Activation of plasmacytoid dendritic cells, modulation of B-cell responses, and immune deviation were proposed to be responsible for the suppressive effect of iNKT cells. We studied the regulatory capacity of human iNKT cells from control subjects and patients with type 1 diabetes (T1D) at disease clinical onset. We demonstrate that control iNKT cells suppress the proliferatio