Protein Folding and Conformational Diseases. “Amyloidogenicity as a driving force for the formation of functional oligomers”
https://doi.org/10.1016/j.jsb.2020.107604
Highlights
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Globular domains flanking amyloid-forming regions can prevent the formation of cross-β amyloids.
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Coarse-grained and rigid body simulation show that these proteins form cross-β oligomers.
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The oligomerisation may provide insight into phase separation of proteins with amyloidogenic regions.
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This study opens up opportunities for design of nano-oligomers with functional domains.
Abstract
Insoluble amyloid fibrils formed by self-assembly of amyloidogenic regions of proteins have a cross-β-structure. In this work, by using targeted molecular dynamics and rigid body simulation, we demonstrate that if a protein consists of an amyloidogenic region and a globular domain(s) and if the link
