Isidre Gibert Gonzalez

Personal information

Email: Isidre.Gibert@uab.cat

Unit: Response Mechanisms to Stress and Disease

Group: Bacterial Molecular Genetics

Category: Professor Titular

Lab phone: 935812050

Academic information and publications


  • Molecular basis of bacterial pathogenesis and antimicrobial agent resistance.
  • Identification and validation of novel antibacterial targets in Gram-negative pathogens.
  • DNA precursors synthesis and bacterial pathogenesis.




Ribonucleotide Reductases of Salmonella Typhimurium: Transcriptional Regulation and Differential Role in Pathogenesis.

Panosa A, Roca I, Gibert I

PLoS ONE 5(6): e11328. 2010


CraA, a major facilitator superfamily efflux pump associated with chloramphenicol resistance in Acinetobacter baumannii.

Roca I, Marti S, Espinal P, Martínez P, Gibert I, Vila J.

Antimicrob Agents Chemother. 2009 Sep;53(9):4013-4.


Cell population heterogeneity in Mycobacterium tuberculosis H37Rv.

Andreu N, Gibert I.

Tuberculosis (Edinb). 2008 Nov;88(6):553-9.


NrdI essentiality for class Ib ribonucleotide reduction in Streptococcus pyogenes.

Roca I, Torrents E, Sahlin M, Gibert I, Sjöberg BM.

J Bacteriol. 2008 Jul;190(14):4849-58.


Fumarate and nitrate reduction (FNR) dependent activation of the Escherichia coli anaerobic ribonucleotide reductase nrdDG promoter.

Roca I, Ballana E, Panosa A, Torrents E, Gibert I.

Int Microbiol. 2008 Mar;11(1):49-56.


The open reading frame present in the nrdEF cluster of Corynebacterium ammoniagenes is a transcriptional regulator belonging to the GntR family.

Torrents E, Roca I, Gibert I.

Curr Microbiol. 2004 Sep;49(3):152-7.


Neutral red staining of cells of a sulfolipid-deficient Mycobacterium tuberculosis pks2 mutant proves that sulfolipids are not responsible for this cytochemical reaction.

Andreu N, Gibert I, Luquin M, Kolattukudy PE, Sirakova T.

J Clin Microbiol. 2004 Mar;42(3):1379-80.


Mycobacterium smegmatis displays the Mycobacterium tuberculosis virulence-related neutral red character when expressing the Rv0577 gene.

Andreu N, Soto CY, Roca I, Martín C, Gibert I.

FEMS Microbiol Lett. 2004 Feb 16;231(2):283-9.


Partial characterization of a transposon containing the tet(A) determinant in a clinical isolate of Acinetobacter baumannii.

Ribera A, Roca I, Ruiz J, Gibert I, Vila J.

J Antimicrob Chemother. 2003 Sep;52(3):477-80.


Corynebacterium ammoniagenes class Ib ribonucleotide reductase: transcriptional regulation of an atypical genomic organization in the nrd cluster.

Torrents E, Roca I, Gibert I.

Microbiology. 2003 Apr;149(Pt 4):1011-20.


Simple and rapid differentiation of Mycobacterium tuberculosis H37Ra from M. tuberculosis clinical isolates through two cytochemical tests using neutral red and nile blue stains.

Soto CY, Andreu N, Gibert I, Luquin M.

J Clin Microbiol. 2002 Aug;40(8):3021-4.


Ribonucleotide reductases: divergent evolution of an ancient enzyme.

Torrents E, Aloy P, Gibert I, Rodríguez-Trelles F.

J Mol Evol. 2002 Aug;55(2):138-52.


Occurrence of multiple ribonucleotide reductase classes in gamma-proteobacteria species.

Torrents E, Jordan A, Karlsson M, Gibert I.

Curr Microbiol. 2000 Nov;41(5):346-51.


The active form of the R2F protein of class Ib ribonucleotide reductase from Corynebacterium ammoniagenes is a diferric protein.

Huque Y, Fieschi F, Torrents E, Gibert I, Eliasson R, Reichard P, Sahlin M, Sjoberg BM.

J Biol Chem. 2000 Aug 18;275(33):25365-71.


Application of an easy and reliable method for sulfolipid-I detection in the study of its distribution in Mycobacterium tuberculosis strains.

Soto CY, Cama M, Gibert I, Luquin M.

FEMS Microbiol Lett. 2000 Jun 1;187(1):103-7.


The anaerobic (class III) ribonucleotide reductase from Lactococcus lactis. Catalytic properties and allosteric regulation of the pure enzyme system.

Torrents E, Buist G, Liu A, Eliasson R, Kok J, Gibert I, Gräslund A, Reichard P.

J Biol Chem. 2000 Jan 28;275(4):2463-71.


Ribonucleotide reduction in Pseudomonas species: simultaneous presence of active enzymes from different classes.

Jordan A, Torrents E, Sala I, Hellman U, Gibert I, Reichard P.

J Bacteriol. 1999 Jul;181(13):3974-80.


The manganese-containing ribonucleotide reductase of Corynebacterium ammoniagenes is a class Ib enzyme.

Fieschi F, Torrents E, Toulokhonova L, Jordan A, Hellman U, Barbe J, Gibert I, Karlsson M, Sjöberg BM.

J Biol Chem. 1998 Feb 20;273(8):4329-37.


B12-dependent ribonucleotide reductases from deeply rooted eubacteria are structurally related to the aerobic enzyme from Escherichia coli.

Jordan A, Torrents E, Jeanthon C, Eliasson R, Hellman U, Wernstedt C, Barbé J, Gibert I, Reichard P.

Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13487-92.


nrdD and nrdG genes are essential for strict anaerobic growth of Escherichia coli.

Garriga X, Eliasson R, Torrents E, Jordan A, Barbé J, Gibert I, Reichard P.

Biochem Biophys Res Commun. 1996 Dec 4;229(1):189-92.


Cloning of the Rhodobacter sphaeroides hisL gene: unifunctionality of the encoded protein and lack of linkage to other his genes.

Oriol E, Méndez-Alvarez S, Barbé J, Gibert I.

Microbiology. 1996 Aug;142 ( Pt 8):2071-8.


The ribonucleotide reductase system of Lactococcus lactis. Characterization of an NrdEF enzyme and a new electron transport protein.

Jordan A, Pontis E, Aslund F, Hellman U, Gibert I, Reichard P.

J Biol Chem. 1996 Apr 12;271(15):8779-85.


Promoter identification and expression analysis of Salmonella typhimurium and Escherichia coli nrdEF operons encoding one of two class I ribonucleotide reductases present in both bacteria.

Jordan A, Aragall E, Gibert I, Barbe J.

Mol Microbiol. 1996 Feb;19(4):777-90.


Two different operons for the same function: comparison of the Salmonella typhimurium nrdAB and nrdEF genes.

Jordan A, Gibert I, Barbé J.

Gene. 1995 Dec 29;167(1-2):75-9.


Cloning and sequencing of the gyrA gene from the plant pathogen Erwinia carotovora.

Rosanas A, Barbé J, Gibert I.

Gene. 1995 Aug 8;161(1):11-4.


A second class I ribonucleotide reductase in Enterobacteriaceae: characterization of the Salmonella typhimurium enzyme.

Jordan A, Pontis E, Atta M, Krook M, Gibert I, Barbé J, Reichard P.

Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12892-6.


Cloning and sequencing of the genes from Salmonella typhimurium encoding a new bacterial ribonucleotide reductase.

Jordan A, Gibert I, Barbé J.

J Bacteriol. 1994 Jun;176(11):3420-7.


Insertion sequence IS200 fingerprinting of Salmonella typhi: an assessment of epidemiological applicability.

Threlfall EJ, Torre E, Ward LR, Dávalos-Pérez A, Rowe B, Gibert I.

Epidemiol Infect. 1994 Apr;112(2):253-61.


Molecular fingerprinting of Salmonella typhimurium by IS200-typing as a tool for epidemiological and evolutionary studies.

Soria G, Barbé J, Gibert I.

Microbiologia. 1994 Mar-Jun;10(1-2):57-68.


Insertion sequence IS200 can differentiate drug-resistant and drug-sensitive Salmonella typhi of Vi-phage types E1 and M1.

Threlfall EJ, Torre E, Ward LR, Rowe B, Gibert I.

J Med Microbiol. 1993 Dec;39(6):454-8.


Characterization of Salmonella virchow phage types by plasmid profile and IS200 distribution.

Torre E, Threlfall EJ, Hampton MD, Ward LR, Gibert I, Rowe B.

J Appl Bacteriol. 1993 Nov;75(5):435-40.


Relationship between the functional regions of the RecA protein and ATP hydrolysis in UV-irradiated Escherichia coli cells.

Pueyo M, Gibert I, Barbé J.

Mutat Res. 1992 Nov;293(1):21-30.


Nucleotide sequence of the methoxyneurosporene dehydrogenase gene from Rhodobacter sphaeroides: comparison with other bacterial carotenoid dehydrogenases.

Garí E, Toledo JC, Gibert I, Barbé J.

FEMS Microbiol Lett. 1992 May 15;72(1):103-8.


Spontaneous and reversible high-frequency frameshifts originating a phase transition in the carotenoid biosynthesis pathway of the phototrophic bacterium Rhodobacter sphaeroides 2.4.1.

Garí E, Gibert I, Barbé J.

Mol Gen Genet. 1992 Mar;232(1):74-80.


IS200 is not a member of the IS600 family of insertion sequences.

Gibert I, Carroll K, Hillyard DR, Barbé J, Casadesus J.

Nucleic Acids Res. 1991 Mar 25;19(6):1343.


Chromogenic method for rapid isolation of recA-like mutants of gram-negative bacteria.

Barbe J, Fernandez de Henestrosa AR, Calero S, Gibert I.

J Bacteriol. 1991 Jan;173(1):404-6.


Distribution of insertion sequence IS200 in Salmonella and Shigella.

Gibert I, Barbé J, Casadesús J.

J Gen Microbiol. 1990 Dec;136(12):2555-60.


[Comparative study with digoxigenin and biotin markers for the DNA probe identification of genes coding for type TEM beta-lactamases]

Hermida M, Gibert I, Barbé J, Roy C.

Enferm Infecc Microbiol Clin. 1990 Oct;8(8):501-4.


sulA-independent division inhibition in his-constitutive strains of Salmonella typhimurium.

Gibert I, Casadesús J.

FEMS Microbiol Lett. 1990 Jun 1;57(3):205-10.


Cyclic AMP stimulates transcription of the structural gene of the outer-membrane protein OmpA of Escherichia coli.

Gibert I, Barbé J.

FEMS Microbiol Lett. 1990 Mar 15;56(3):307-11.


Measurement of in vivo expression of nrdA and nrdB genes of Escherichia coli by using lacZ gene fusions.

Gibert I, Calero S, Barbé J.

Mol Gen Genet. 1990 Feb;220(3):400-8.


Induction of SOS genes in Escherichia coli and mutagenesis in Salmonella typhimurium by fluoroquinolones.

Ysern P, Clerch B, Castańo M, Gibert I, Barbé J, Llagostera M.

Mutagenesis. 1990 Jan;5(1):63-6.


Evidence for a specific regulation of recA gene transcription in Escherichia coli.

Villaverde A, Gibert I, Barbé J.

Mutat Res. 1988 May;199(1):123-30.


Regulation of ubiG gene expression in Escherichia coli.

Gibert I, Llagostera M, Barbé J.

J Bacteriol. 1988 Mar;170(3):1346-9.


Modulating action of cyclic AMP on the expression of two SOS genes in Escherichia coli K-12.

Barbé J, Gibert I, Guerrero R.

Can J Microbiol. 1987 Aug;33(8):704-8.


DNA repair systems in the phototrophic bacterium Rhodobacter capsulatus.

Barbé J, Gibert I, Llagostera M, Guerrero R.

J Gen Microbiol. 1987 Apr;133(4):961-6.


5-Azacytidine: survival and induction of the SOS response in Escherichia coli K-12.

Barbé J, Gibert I, Guerrero R.

Mutat Res. 1986 Jul;166(1):9-16.