IBB UAB

Julia Lorenzo Rivera

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Personal information

Email: julia.lorenzo@uab.es

Unit: Applied Proteomics and Protein Engineering

Group: Protein Engineering and Nanomedicine

Category: Professor Agregat

Lab phone: 935868957

Academic information and publications

Research:

Areas of expertise and interest

Structure-Function Relationships of Macromolecules and Protein-Protein Interactions.

Production of Recombinant Proteins, Purification and Characterization of Metallopeptidases and their inhibitors. Biotechnological and biomedical applications.

Anticancer drug studies.

 

Professional Experience

Member of the Institute of Biotechnology and Biomedicine since 1993.

 

Other Activities:

1 Ph.D. thesis and 4 Master thesis (or Tesinas) supervised and co-supervised.

 

Participation in R+D Projects

Participation in 18 competitive projects from National and International-European (EC) Programs since 1994

Most recent grant: BIO2007-68046-C02-01 Interactómica, análisis estructural y búsqueda de fármacos: aplicaciones a sistemas proteolíticos y a modelos amiloidogénicos (S1). IP: FJ Avilés

PATENTS

- Aviles F.X., Lorenzo J., Rodriguez Vega M., Querol E., Bautista M., Diez A., Bautista J.M. AGENTES TERAPÉUTICOS PARA EL TRATAMIENTO DE LA MALARIA . N. de solicitud: P20060325 País de prioridad: España. Fecha de prioridad: 22/12/06. Entidad titular: Universidad Autónoma de Barcelona y Universidad Complutense de Madrid. Extendida a PCT internacional en diciembre 2007.

 

 


Publications

  1. Peracaula R, Cleary KR, Lorenzo J, de Llorens R, Frazier ML. Human Pancreatic Ribonuclease 1: Expression and distribution in pancreatic adenocarcinoma. Cancer. 2000. 89(6): 1252-1258.

  2. Moradell S, Lorenzo J, Rovira A, Robillard MS, Aviles FX, Moreno V, de Llorens R, Martinez MA, Reedijk J, Llobet A. Platinum complexes of diaminocarboxylic acids and their ethyl ester derivatives: the effect of the chelate ring size on antitumor activity and interactions with GMP and DNA. 2003. J Inorg Biochem; 96(4): 493-502.

  3. Arolas JL, Lorenzo J, Rovira A, Vendrell J, Aviles FX, Ventura S. Secondary binding site of the potato carboxypeptidase inhibitor. Contribution to its structure, folding, and biological properties. Biochemistry. 2004; 43(24):7973-82.

  4. Arolas JL, Bronsoms S, Lorenzo J, Aviles FX, Chang JY, Ventura S. Role of kinetic intermediates in the folding of leech carboxypeptidase inhibitor. J Biol Chem. 2004; 279(36): 37261-70.

  5. Moradell S, Lorenzo J, Rovira A, van Zutphen S, Aviles FX, Moreno V, de Llorens R, Martinez MA, Reedijk J, Llobet A. Water-soluble platinum(II) complexes of diamine chelating ligands bearing amino-acid type substituents: the effect of the linked amino acid and the diamine chelate ring size on antitumor activity, and interactions with 5'-GMP and DNA. J Inorg Biochem. 2004; 98(11):1933-46.

  6. Arolas JL, Lorenzo J, Rovira A, Castella J, Aviles FX, Sommerhoff CP. A carboxypeptidase inhibitor from the tick Rhipicephalus bursa: isolation, cDNA cloning, recombinant expression, and characterization. J Biol Chem. 2005; 280(5):3441-8.

  7. Arolas JL, Popowicz GM, Lorenzo J, Sommerhoff CP, Huber R, Aviles FX, Holak TA. The three-dimensional structures of tick carboxypeptidase inhibitor in complex with A/B carboxypeptidases reveal a novel double-headed binding mode. J Mol Biol. 2005; 350(3): 489-98.

  8. Sitja-Arnau M, Molina MA, Blanco-Aparicio C, Ferrer-Soler L, Lorenzo J, Aviles FX, Querol E, de Llorens R. Mechanism of action of potato carboxypeptidase inhibitor (PCI) as an EGF blocker. Cancer Lett. 2005; 226(2): 169-84.

  9. Ruiz J, Cutillas N, Vicente C, Villa MD, Lopez G, Lorenzo J, Aviles FX, Moreno V, Bautista D. New palladium(II) and platinum(II) complexes with the model nucleobase 1-methylcytosine: antitumor activity and interactions with DNA. Inorg Chem. 2005; 44(21):7365-76.

  10. Martinez A, Lorenzo J, Prieto MJ, de Llorens R, Font-Bardia M, Solans X, Aviles FX, Moreno V. SYNTHESIS, CHARACTERISATION AND BIOLOGICAL ACTIVITY OF trans-PLATINUM(II) AND trans-PLATINUM(IV) COMPOUNDS WITH 4-HYDROXYMETHYLPYRIDINE. ChemBiochem. 2005; 6(11):2068-77.

  11. Ruiz J, Lorenzo J, Sanglas L, Cutillas N, Vicente C, Villa MD, Aviles FX, Lopez G, Moreno V, Perez J, Bautista D. Palladium(II) and platinum(II) organometallic complexes with the model nucleobase anions of thymine, uracil, and cytosine: antitumor activity and interactions with DNA of the platinum compounds. Inorg Chem. 2006 Aug 7; 45(16):6347-60.

  12. Martinez A, Lorenzo J, Prieto MJ, Font-Bardia M, Solans X, Aviles FX, Moreno V. Influence of the position of substituents in the cytotoxic activity of trans platinum complexes with hydroxymethyl pyridines. Bioorg Med Chem. 2007;15(2):969-79.

  13. Rodriguez de la Vega M, Sevilla RG, Hermoso A, Lorenzo J, Tanco S, Diez A, Fricker LD, Bautista JM, Avilés FX. Nna1-like proteins are active metallocarboxypeptidases of a new and diverse M14 subfamily. FASEB J. 2007 Mar;21(3):851-65.

  14. Mounir M, Lorenzo J, Ferrer M, Prieto MJ, Rossell O, Avilès FX, Moreno V. DNA interaction and antiproliferative behavior of the water soluble platinum supramolecular squares [(en)Pt(N-N)]4(NO3)8 (en=ethylenediamine, N-N=4,4'-bipyridine or 1,4-bis(4-pyridyl)tetrafluorobenzene). J Inorg Biochem. 2007 Apr;101(4):660-6.

  15. Montaña AM, Bernal FJ, Lorenzo J, Farnós C, Batalla C, Prieto MJ, Moreno V, Avilés FX, Mesas JM, Alegre MT. Synthesis, characterization and antiproliferative studies of the enantiomers of cis-[(1,2-camphordiamine)dichloro]platinum(II) complexes. Bioorg Med Chem. 2008 Feb 15;16(4):1721-37.

  16. de Mier-Vinué J, Lorenzo J, Montaña AM, Moreno V, Avilés FX. Synthesis, DNA interaction and cytotoxicity studies of cis-{[1, 2-bis(aminomethyl)cyclohexane]dihalo} platinum(II) complexes. J Inorg Biochem. 2008 Apr;102(4):973-87.

  17. Martínez A, Moreno V*, Sanglas L, de Llorens R, Avilés FX, Lorenzo J*. Study by HPLC-MS of the interaction of platinum antitumor complexes with potato carboxypeptidase inhibitor (PCI). Bioorg Med Chem. 2008 Jul 15;16(14):6832-40.

  18. Ruiz J, Lorenzo J, Vicente C, López G, María López-de-Luzuriaga J, Monge M, Avilés FX, Bautista D, Moreno V, Laguna A. New palladium(II) and platinum(II) complexes with 9-aminoacridine: structures, luminiscence, theoretical calculations, and antitumor activity. Inorg Chem. 2008 Aug 4;47(15):6990-7001.

  19. Ekström U, Wallin H, Lorenzo J, Holmqvist B, Abrahamson M, Avilés FX. Internalization of cystatin C in human cell lines. FEBS J. 2008 Sep;275(18):4571-82.

  20. Parajó Y, de LLorens R, Moreno V, Prieto MJ, Sánchez-González M, Sordo J, Avilés FX, Lorenzo J. Cytotoxicity studies of [PtCl2(H2bim)] (H2bim = 2,2’-biimidazole). Study of its interaction with a small protein PCI (Potato Carboxypeptidase Inhibitor). Inorg. Chim. Acta. 2009 362(3):946-952.