IBB UAB

Ignasi Roig Navarro

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Personal information

Email: ignasi.roig@uab.cat

Unit: Genomics in Evolution and Disease

Group: Genome Integrity and Instability

Category: Professor Agregat

Lab phone: 935811211

Academic information and publications

Research:
Education:
1999 B.S. Biology, Universitat Autònoma de Barcelona, Barcelona, Spain
2002 Master in Cell Biology, Universitat Autònoma de Barcelona, Barcelona, Spain
2005 Ph.D. Cell Biology, Universitat Autònoma de Barcelona, Barcelona, Spain
 
Positions and Appointments:
09/98-07/99 Undergraduate student at the Cell Biology, Physiology and Immunology Department, UAB.
09/99-02/01 Associate professor at the Cell Biology, Physiology and Immunology Department, UAB, Spain.
06/03-08/03 Postgraduate Researcher at Dr. Ashley Lab, Yale University, New Haven, USA.
07/05-12/05 Postdoctoral Fellow at the Cell Biology, Physiology and Immunology Department, UAB, Spain.
02/06-07/08 Postdoctoral Fellow, Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, USA.
08/08-01/10 Research Fellow, Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, USA.
09/09-03/18 Lecturer, Cytology and Histology Unit, Dept. Cell Biology, Physiology & Immunology Universitat Autònoma de Barcelona.
04/18             Associate professor, Cytology and Histology Unit, Dept. Cell Biology, Physiology & Immunology Universitat Autònoma de Barcelona.
 
Honors and Awards:
2001-2005 Predoctoral fellowship from the Spanish Government (Ministerio de Educación y Cultura, programa de Formación de Profesorado Universitario).
2001-2003 Predoctoral travel fellowships Spanish Government (Ministerio de Educación y Cultura, programa de Formación de Profesorado Universitario):
- Host institution: Free University of Brussels, Belgium, 9-12/2001.
- Host institution: Max Planck Institute for Molecular Genetics, Germany, 8-10/2002.
- Host institution: Yale University, USA, 7-8/2003.
2005 Ph.D., Excellent cum laude, Universitat Autònoma de Barcelona.
2005 Extraordinary award for the best defended thesis of the Department of Cell Biology, Physiology and Immunology of the Universitat Autònoma from Barcelona.
2005,2006 Nominee to the 7th and 8th Royan International Research Award on Reproductive Biomedicine & Stems Cells, Teheran, Iran.
2008 “Professor Lector” Acreditation, Agència de la Qualitat Universitària (AQU), Spain.
2008,2009 Invited professor, Cell Biology PhD program, Universitat Autònoma de Barcelona, Spain.
2009 Beatriu de Pinós Fellowship, Generalitat de Catalunya, Spain.
2010 Short term travel fellowship, European Molecular Biology Organization (EMBO), Germany.
2010 Research visit fellowship BE-DGR, AGAUR-Generalitat de Catalunya. Host Institute: Memorial Sloan-Kettering Cancer Center, USA, 7-8/2010
2011 Ramón y Cajal fellowship, Ministerio Ciencia e Innovación, Spain. (Awarded-Declined). 
2011 Young Investigator Award, Aposta program, Universitat Autònoma de Barcelona, Spain.
2012 "Profesor Titular" Acreditation, ANECA, Spain
2013, 2014 Profesor invitado, programa de Máster en Biología Celular, UAM-UCM-UAH
2018  Beca de Investigación, Fundación Dexeus Mujer, España.
2019  Miembro comisión evaluadora del XII Premi Antoni Prevosti de Biologia Evolutiva, Societat Catalana de Biologia.
2019  Miembro comisión evaluadora del “EMBO Outstanding Poster Prize Award” and “Société Française de Génétique Poster Prize”, EMBO meiosis meeting.
2020  Miembro comisión evaluadora del BioRender Annual Graphical Abstract Contest.

 (For more information please visit https://webs.uab.cat/meiosis/)

 


Publications
  1. Roig I., Vanrell I., Ortega A., Cabero Ll., Egozcue E., Garcia M. The use of foetal ovarian stromal cell culture for cytogenetic diagnosis. Cytotechnology 2003 41:45-49.
  2. Roig, I.*, Liebe, B.*, Egozcue, J., Cabero, Ll., Garcia, M. and Scherthan, H. Female-specific features of recombinational double-stranded DNA repair in relation to synapsis and telomere dynamics in human oocytes. Chromosoma 2004 113: 22-33. (* Co-first authors).
  3. Roig I.,  Robles P., Garcia R., Egozcue J., Liebe B.,  Scherthan H, Garcia M. Chromosome 18 pairing behavior in human trisomic oocytes.         Presence of an extra chromosome extends bouquet stage. Reproduction 2005 129: 565-575.
  4. Roig I, Robles P., Garcia R., Martin M., Egozcue J., Cabero Ll., Barambio S., Garcia M. Evolution of the meiotic prophase and of the chromosome pairing process during human fetal ovarian development. Human Reproduction 2005 20:2463-9.
  5. Roig I., Garcia R., Robles P., Cortvrindt R., Egozcue J., Smitz J., Garcia M. Human fetal ovarian culture permits meiotic progression and chromosome-pairing process. Human Reproduction. 2006 6:1359-67.
  6. Robles P.*, Roig I.*, Garcia R., Ortega A., Egozcue J., Cabero Ll. and Garcia M. Pairing and Synapsis in oocytes from female fetuses with euploid and aneuploid chromosome complements. Reproduction 2007 133:899-907. (* Co-first authors).
  7. Barchi M.*, Roig I.*, Di Giacommo, de Roiij DG., Keeney S. and Jasin M. ATM promotes the obligate XY crossover and both crossover control and chromosome axis integrity on autosomes. PLoS Genet. 2008 May 23;4(5):e1000076. (* Co-first authors).
  8. Roig I., Keeney S. Probing meiotic recombination decisions. Dev Cell. 2008 Sep;15(3):331-2.
  9. Garcia-Cruz R., Roig I. and Garcia-Caldes M. Maternal origin of the human aneuploidies. Are homologue synapsis and recombination to blame? Notes (learned) from the underbelly. Genome Dyn. 2009; 5:128-36.
  10. Garcia-Cruz R., Roig I., Robles P., Scherthan H. and Garcia Caldes M. ATR implication in DSB signaling and in the pachytene checkpoint in human oocytes. Reprod Biomed Online. 2009 Jan;18(1):37-44.
  11. Robles P., Roig I., Garcia R., Brieño M., Martin M., Barbero J.L., Cabero Ll. and Garcia Caldes M.  Analysis of the recombination process along chromosome 21 during human female pachytene stage. Reprod BioMed Online 2009 Jun;18(6):784-94.
  12. Wojtasz L., Daniel K., Roig I., Bolcun-Filas E.,  Xu H.,  Boonsanay V., Eckmann C., Cooke H.J., Jasin M.,  Keeney S., McKay M.J. and Toth A. Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA- PLoS Genet. 2009 Oct;5(10):e1000702.
  13. Garcia-Cruz R, Casanovas A, Brieño-Enríquez M, Robles P, Roig I, Pujol A, Cabero L, Durban M, Garcia Caldés M. Cytogenetic analyses of human oocytes provide new data on non-disjunction mechanisms and the origin of trisomy 16. Hum Reprod. 2010 Jan;25(1):179-91.
  14. Brieño-Enríquez MA, Robles P, García-Cruz R, Roig I, Cabero L, Martínez F, Garcia Caldés M. A new culture technique that allows in vitro meiotic prophase development of fetal human oocytes. Hum Reprod. 2010 Jan;25(1):74-84.
  15. Lu WJ, Chapo J, Roig I, Abrams JM. Meiotic recombination provokes functional activation of the p53 regulatory network. Science. 2010 Jun 4;328(5983):1278-81.
  16. Garcia-Cruz R, Brieño MA, Roig I, Grossmann M, Velilla E, Pujol A, Cabero L, Pessarrodona A, Barbero JL, Caldés MG. Dynamics of cohesin proteins REC8, STAG3, SMC1 beta and SMC3 are consistent with a role in sister chromatid cohesion during meiosis in human oocytes. Hum Reprod. 2010 Sep;25(9):2316-27.
  17. Roig I, Dowdle JA, Toth A, de Rooij DG, Jasin M, Keeney S. Mouse TRIP13/PCH2 is required for recombination and normal higher-order chromosome structure during meiosis. PLoS Genet. 2010 Aug 12;6(8). pii: e1001062.
  18. Roig I, Brieño-Enríquez MA, Garcia Caldés M. Meiosis in a bottle: New approaches to overcome mammalian meiocyte study limitations. Genes. 2011, 2(1): 152-168.
  19. Daniel K, Lange J, Hached K, Fu J, Anastassiadis K, Roig I, Steward AF, Wassmann K, Jasin M, Keeney S, Toth A. Meiotic homologue alignment and its quality check are controlled by mouse Hormad1. Nature Cell Biology 2011 May; 13(5):599-610.
  20. Yin Y, Lin C, Tae Kim S, Roig I, Chen H, Liu L, Veith GM, Jin RU, Keeney S, Jasin M, Moley K, Zhou P, Ma L. The E3 ubiquitin ligase cullin 4A regulates meiotic progression in mouse spermatogenesis. Dev Biol. 2011 Aug 1; 356(1): 51-62. 
  21. Brieño-Enríquez MA, Robles P, Camats-Tarruella N, Garcia-Cruz R, Roig I, Cabero L, Martínez F, Garcia Caldés M. Human meiotic progression and recombination are affected by Bisphenol A exposure during in vitro human oocyte development. Human Reprod. 2011, Oct; 26(10): 2807-18.
  22. Churchman ML, Roig I, Keeney S, Jasin M, Sherr CJ. Transient Arf expression in spermatogonia prevents p53-dependent elimination of spermatocytes during male germ cell development. PLoS Genet. 2011 Jul; 7(7): e1002157.
  23. Brieño-Enríquez MA, Reig-Viader R, Cabero L, Toran N, Martínez F, Roig I, Garcia Caldés M. Gene expression is altered after Bisphenol A exposure in human fetal oocytes in vitro. Mol Hum Reprod. 2012 Apr; 18(4): 171-83.
  24. Cole F, Kauppi L, Lange J, Roig I, Wang R, Keeney S, Jasin M. Homeostatic control of recombination is implemented progressively in mouse meiosis. Nature Cell Biology 2012 Mar 4. Doi:1038/ncb2451
  25. Stracker TH, Roig I, Knobel PA, Marjanović M.The ATM signaling network in development and disease. Front Genet. 2013 Mar 25;4:37. doi: 10.3389/fgene.2013.00037.
  26. Robles P, Roig I, Garcia R, Brieño-Enríquez M, Martin M, Cabero L, Toran N, Garcia Caldés M. Presence of an extra chromosome alters meiotic double-stranded break repair dynamics and MLH1 foci distribution in human oocytes. 2013 Mar;122(1-2):93-102. doi: 10.1007/s00412-012-0394-5. Epub 2013 Jan 4.
  27. Muños-Fuentes V, Marcet-Ortega M, Alkorta-Aranburu G, Linde-Forsberg C, Morrell JM, Manzano-Piedras E, Söderberg A, Daniel K, Villalba A, Toth A, Di Rienzo A, Roig I, Vila C. Strong artificial selection in domestic mammals did not result in an increased recombination rate. Molecular Biology and Evolution. 2015 Feb; 32(2):510-23.
  28. Pacheco S, Marcet-Ortega M, Lange J, Jasin M, Keeney S, Roig I. The ATM-signaling cascade promotes recombination-dependent pachytene arrest in mouse spermatocytes. PLoS Genet 2015 Mar 13; 11(3):e1005017.
  29. Marjanović M, Sánchez-Huertas C, Terré B, Gómez R, Scheel JF, Pacheco S, Knobel PA, Martínez-Marchal A, Aivio S, Palenzuela L, Wolfrum U, McKinnon PJ, Suja JA, Roig I, Costanzo V, Lüders J, Stracker T. CEP63 deficiency promotes p53 dependent microcephaly and reveals a role for the centrosome in meiotic recombination. Nature Communications 2015 Jul 9;6:7676.
  30. Testa E, Nardozi D, Antinozzi C, Faieta M, Di Cecca S, Caggiano C, Fukuda T, Bonanno E, Zhenkun L, Maldonado-Linares A, Roig I, Di Giacomo M, Barchi M. H2AX and MDC1 protect genomic integrity in male germ cells by promoting recombination and activation of the recombination-dependent checkpoint. J Cell Sci. 2018 Mar 20;131(6). pii: jcs214411.    
  31. Marcet-Ortega M, Pacheco S, Martínez-Marchal A, Castillo H, Flores E, Jasin M, Keeney S, Roig I. p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes. PLoS Genet. 2017 Jun 15;13(6):e1006845.
  32. Pacheco S, Maldonado-Linares A, Marcet-Ortega M, Rojas C, Martinez-Marchal A, Fuentes-Lazaro J, Lange J, Jasin M, Keeney S, Fernandez-Capetillo O, Garcia-Caldes M, Roig I. ATR Is Required To Complete Meiotic Recombination In Mice. Nature Communications 2018; 9(1):2622.
  33. Widger A, Mahadevaiah SK, Lange J, ElInati E, Zohren J, Hirota T, Pacheco S, Maldonado-Linares A, Stanzione M, Ojarikre O, Maciulyte V, de Rooij DG, Tóth A, Roig I, Keeney S, Turner JMA. ATR is a multifunctional regulator of male mouse meiosis. Nature Communications. 2018; 9(1):2622.
  34. Abreu CA, Prakash R, Romanienko PJ, Roig I, Keeney S, Jasin M. Shu complex SWS1-SWSAP1 is required for mouse meiotic recombination in concert with the BRCA2 C terminus. Nature Communications 2018; 9(1):3961.
  35. Pacheco S, Garcia-Caldés M, Roig I. ATR function is indispensable to allow proper mammalian follicle development. Chromosoma. 2019 Sep;128(3):489-500.
  36. Gómez-H L, Felipe-Medina N, Condezo YB, Garcia-Valiente R, Ramos I, Roig I, Sanchez-Martín M, de Rooij D, Llano E, Pendás AM. Spermatoproteasome-deficient mice are proficient in meiotic DNA repair but defective in meiotic exit. PLoS Genet. 2019 Aug 22;15(8):e1008316.
  37. Martínez-Marchal A, Huang Y, Guillot-Ferriols MT, Ferrer-Roda M, Guixé A, Garcia-Caldés M, Roig I. The DNA damage response is required for oocyte cyst breakdown and follicle formation in mice. PLoS Genet 2020 Nov 18;16(11):e1009067.
  38. Hoffmann ER, Roig I. Cas9 in Human Embryos: On Target but No Repair. Cell 2020 Dec 10;183(6):1464-1466.
  39. Ruth KS, Day FR, Hussain J, Martínez-Marchal A, Aiken CE, Azad A, Thompson DJ, […], Solc P, Murabito JM, Ong KK, Hoffmann ER*, Murray A*,  Roig I*, Perry JRB*. Genetic insights into biological mechanisms governing human ovarian ageing. Nature 2021 Aug;596(7872):393-397 https://doi.org/10.1038/s41586-021-03779-7.  (*co-corresponding authors).   
  40. Sanchez-Donoso I, Ravagni S, Rodríguez-Teijeiro JD, Christmas MJ, Huang Y, Maldonado-Linares A, Puigcerver M, Jiménez-Blasco I, Andrade P, Gonçalves D, Friis G, Roig I, Webster MT, Leonard JA, Vilà C. Massive genome inversion drives coexistence of divergent morphs in common quails. Curr Biol. 2022 Jan 24;32(2):462-469
  41. Marcet-Ortega M, Maldonado-Linares A, López-Panadés M, Roig I. p53 Controls Meiotic Prophase Progression and Crossover Formation. Int J Mol Sci. 2022 Aug 29;23(17):9818. 
  42. Huang Y, Roig I. Genetic control of meiosis surveillance mechanisms in mammals. Front Cell Dev Biol. 2023 Feb 23;11:1127440. 
  43. Huang Y, Bucevic N, Coves C, Felipe-Medina N, Nikou N, Madrid-Sandín C, Ferrer Miralles N, Iborra A, Pendás AM, Roig I. Bend2 regulates the ovarian reserve in mice. Elife. https://doi.org/10.7554/eLife.96052.1