Raul Castaño García

Personal information

Email: raul.castano@uab.es

Unit: Response Mechanisms to Stress and Disease

Group: Molecular Immunology

Category: Professor Agregat

Lab phone: 935814802

Academic information and publications


A. R. Castaño. "Antigen processing and presentation II". Inmunología 2003; 23: 243-247 

B. Gil-Torregrosa, A. R. Castaño, D. Lopez, M. del Val. "Furin-dependent proteolytic maturation of antigenic proteins in the secretory pathway as a general MHC class I antigen presentation pathway". Traffic 2000; 1: 641-65

B. Gil-Torregrosa, A. R. Castaño, M. Del Val. "MHC class I viral antigen processing in the secretory pathway defined by the trans-Golgi network protease furin". J. Exp. Med. 1998; 8: 1105-1116.

M. Mandal, X.R. Chen, M.L. Alegre, N.M. Chiu, Y.H. Chen, A. R. Castaño, C.R. Wang. "Tissue distribution and biochemical characterization of murine CD1 molecules". Molecular Immunology ­1998; 35: 525-536. 

Z.H. Zeng, A. R. Castaño, B. Segelke, E.A. Stura, P.A. Peterson, I.A. Wilson. “The crystal structure of murine CD1: an MHC-like fold with a large hydrophobic antigen binding groove. Science 1997; 277: 339-345.

S. Tangri, H.R. Holcombe, A. R. Castaño,  J.E.W. Miller,  M. Teitell, W.D. Huse,  P. A. Peterson, M. Kronenberg. "Antigen presentation function of the mouse CD1 molecule". Annals N. Y. Acad. Science 1996: 288-296 

A. R. Castaño, S. Tangri, J.E.W. Miller, H.R. Holcombe, M.R. Jackson, W.D. Huse, M. Kronenberg, P. A. Peterson. "Peptide binding and presentation by mouse CD1". Science 1995; 269: 223-226

H.R. Holcombe,  A. R. Castaño, H. Cheroutre, M. Teitell, P. Peterson & M. Kronenberg. "Nonclassical behavior of the thymus leukemia antigen: peptide transporter independent expression of a nonclassical class I molecule". J. Exp. Med 1995; 181: 1433-1443

C.R. Wang, A. R. Castaño, P.A. Peterson, C. Slaughter, K. Fischer-Lindahl, J. Deisenhofer. "Nonclassical binding of formylated peptide in crystal structure of MHC Class Ib molecules H2-M3". Cell 1995; 82: 655-664

H. Cheroutre, S. Tangri, H.R. Holcombe, A. R. Castaño,  M. Teitell, J.E.W. Miller, S. Cardell, C. Benoist, D. Mathis, W.D. Huse,  P. A. Peterson, M. Kronenberg. "Antigen-presenting function of the TL antigen and mouse CD1 molecules". Imm. Rev. 1995; 147: 31-52. 

A. R. Castaño & J.A. López de Castro. "Structure of the HLA-A2.5 subtype: further evidence for selection-driven diversification of HLA-A2 antigens". Immunogenetics 1992; 35: 344-346.

A. R. Castaño & J.A. López de Castro. "Structure of the HLA-A*0204 antigen, found in South American Indians. Spatial clustering of HLA-A2 subtype polymorphism". Immunogenetics 1991; 34: 281-285.


 A. R. Castaño, P. Lauzurica, N. Doménech, J.A. López de Castro. "Structural identity between HLA-A2 antigens differentially recognized by alloreactive  cytotoxic T lymphocytes". J. Immunol. 1991; 146: 2915-2920

N. Doménech, A. R. Castaño, E. Goulmy & J.A. López de Castro. "Molecular analysis of HLA-A2.4 functional variant KLO: close structural and evolutionary relatedness to the HLA-A2.2 subtype". Immunogenetics 1988; 28: 143-152. 

A. R. Castaño, A. Ezquerra, N. Doménech & J.A. López de Castro. "An HLA-A2 population variant with structural polymorphism in the a3 region". Immunogenetics 1988; 27: 345-355. 

N. Doménech, A. Ezquerra, A. R. Castaño & J. A. López de Castro. "Structural analysis of an HLA-A2.4 functional variant KNE defined by cytolytic T lymphocytes. Implications for the mapping of HLA-A2-specific T-cell epitopes". Immunogenetics 1988; 27: 196-202. 

A.J. García Tejedor,  A. R. Castaño, F. Morán & F. Montero."Studies on evolutionary and selective properties of Hypercycles using a Monte-Carlo method". J. Mol. Evol. 1987; 26: 294-300.  


A. R. Castaño & J.A. López de Castro. "Selection-driven evolution of HLA-A2 antigens". In "HLA 1991". Vol 2. Eds. K.Tsuji, M. Aizawa, T. Sasazuki. Oxford University Press. Pg 205-210 (1992).


J.A. López de Castro,  A. R. Castaño, B. Galocha, D. Rojo & J.A. Villadangos. "T cell epitope mapping on HLA-A2 and -B27". In "HLA 1991". Vol 2. Eds. K. Tsuji, M. Aizawa, T. Sasazuki. Oxford Science Publications. Pg 559-564 (1992).

 A.R. Castaño & J.A. López de Castro. "HLA-A2 allorecognition and subtype diversification". In "T lymphocytes: structure, functions, choices". (Ed. F. Celada, B. Pernis) Plenum Press. Pg 89-95 (1992).

  L. Karlson, A. R. Castaño, P. A. Peterson. " Principles of antigen processing and presentation". In "Essentials of mucosal immunology". (Ed M. Kagnoff and H. Kiyono) Academic Press . Pg 3-28 (1996).

B. C. Sydora, R. Aranda, S. Tangri, H.R. Holcombe, V. Camerini, A. R. Castaño,  J.E.W. Miller, S. Cardell, W.D. Huse,  P. A. Peterson, H. Cheroutre,  M. Kronenberg. "Lymphocyte-epithelial cross talk in the intestine: do nonclassical class I molecules have a big part in the dialogue?. In "Essentials of mucosal immunology"(Ed M. Kagnoff and H. Kiyono) Academic Press Pg. 205-226 (1996).

 I.A. Wilson, K.C. Garcia, M. Degano, R.L. Stanfield, Z. Zeng, B. Segelke, E.A. Stura, A.R. Castaño, D.A. Jewell, A. Brunmark, M.R. Jackson, P.A. Peterson, L. Teyton. "Structural basis of cellular immune recognition" In "HLA and Disease - The molecular basis" (Ed. A. Svejgaard, S. Buus and L. Fugger) Alfred Benzon Symposium series, 40. Pg 46-60 (1997).