{"id":4017,"date":"2021-06-09T16:24:30","date_gmt":"2021-06-09T15:24:30","guid":{"rendered":"https:\/\/ibb.uab.cat\/?p=4017"},"modified":"2021-06-09T16:24:31","modified_gmt":"2021-06-09T15:24:31","slug":"protein-folding-and-conformational-diseases-critical-assessment-of-protein-intrinsic-disorder-prediction","status":"publish","type":"post","link":"https:\/\/ibb.uab.cat\/index.php\/2021\/06\/09\/protein-folding-and-conformational-diseases-critical-assessment-of-protein-intrinsic-disorder-prediction\/","title":{"rendered":"Protein Folding and Conformational Diseases: &#8220;Critical assessment of protein intrinsic disorder prediction&#8221;"},"content":{"rendered":"\n<p><a href=\"https:\/\/www.nature.com\/nmeth\"><em>Nature Methods<\/em><\/a>\u00a0<strong>volume\u00a018<\/strong>,\u00a0pages 472\u2013481 (2021)<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1038\/s41592-021-01117-3\">https:\/\/doi.org\/10.1038\/s41592-021-01117-3<\/a><\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-style-default\"><img loading=\"lazy\" width=\"1024\" height=\"403\" src=\"https:\/\/ibb.uab.cat\/wp-content\/uploads\/salva_natucommubi2-1024x403.jpg\" alt=\"\" class=\"wp-image-4018\" srcset=\"https:\/\/ibb.uab.cat\/wp-content\/uploads\/salva_natucommubi2-1024x403.jpg 1024w, https:\/\/ibb.uab.cat\/wp-content\/uploads\/salva_natucommubi2-300x118.jpg 300w, https:\/\/ibb.uab.cat\/wp-content\/uploads\/salva_natucommubi2-768x302.jpg 768w, https:\/\/ibb.uab.cat\/wp-content\/uploads\/salva_natucommubi2-1536x605.jpg 1536w, https:\/\/ibb.uab.cat\/wp-content\/uploads\/salva_natucommubi2-2048x806.jpg 2048w, https:\/\/ibb.uab.cat\/wp-content\/uploads\/salva_natucommubi2-548x216.jpg 548w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2 id=\"Abs1\">Abstract<\/h2>\n\n\n\n<p>Intrinsically disordered proteins, defying the traditional protein structure\u2013function paradigm, are a challenge to study experimentally. Because a large part of our knowledge rests on computational predictions, it is crucial that their accuracy is high. The Critical Assessment of protein Intrinsic Disorder prediction (CAID) experiment was established as a community-based blind test to determine the state of the art in prediction of intrinsically disordered regions and the subset of residues involved in binding. A total of 43\u2009methods were evaluated on a dataset of 646\u2009proteins from DisProt. The best methods use deep learning techniques and notably outperform physicochemical methods. The top disorder predictor has&nbsp;<em>F<\/em><sub>max<\/sub>\u2009=\u20090.483 on the full dataset and&nbsp;<em>F<\/em><sub>max<\/sub>\u2009=\u20090.792 following filtering out of bona fide structured regions. Disordered binding regions remain hard to predict, with&nbsp;<em>F<\/em><sub>max<\/sub>\u2009=\u20090.231. Interestingly, computing times among methods can vary by up to four orders of magnitude.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nature Methods\u00a0volume\u00a018,\u00a0pages 472\u2013481 (2021) https:\/\/doi.org\/10.1038\/s41592-021-01117-3 Abstract Intrinsically disordered proteins, defying the traditional protein structure\u2013function paradigm, are a challenge to study experimentally. Because a large part of our knowledge rests on computational predictions, it is crucial that their accuracy is high. The Critical Assessment of protein Intrinsic Disorder prediction (CAID) experiment was established as a community-based [&hellip;]<\/p>\n","protected":false},"author":65,"featured_media":4018,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[4],"tags":[],"_links":{"self":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/4017"}],"collection":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/users\/65"}],"replies":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/comments?post=4017"}],"version-history":[{"count":1,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/4017\/revisions"}],"predecessor-version":[{"id":4019,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/4017\/revisions\/4019"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/media\/4018"}],"wp:attachment":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/media?parent=4017"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/categories?post=4017"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/tags?post=4017"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}