{"id":3618,"date":"2020-10-14T10:49:28","date_gmt":"2020-10-14T09:49:28","guid":{"rendered":"https:\/\/ibb.uab.cat\/?p=3618"},"modified":"2020-10-14T11:43:27","modified_gmt":"2020-10-14T10:43:27","slug":"molecular-biology-immunodominant-proteins-p1-and-p40-p90-from-human-pathogen-mycoplasma-pneumoniae","status":"publish","type":"post","link":"https:\/\/ibb.uab.cat\/index.php\/2020\/10\/14\/molecular-biology-immunodominant-proteins-p1-and-p40-p90-from-human-pathogen-mycoplasma-pneumoniae\/","title":{"rendered":"Molecular Biology: “Immunodominant proteins P1 and P40\/P90 from human pathogen Mycoplasma pneumoniae”"},"content":{"rendered":"
\n
\n
\"\"https:\/\/www.nature.com\/articles\/s41467-020-18777-y<\/a><\/span><\/pre>\n
Vizarraga, D., Kawamoto, A., Matsumoto, U.\u00a0et al.<\/i>\u00a0Immunodominant proteins P1 and P40\/P90 from human pathogen\u00a0Mycoplasma pneumoniae<\/i>.\u00a0Nat Commun<\/i>\u00a011,\u00a0<\/b>5188 (2020). https:\/\/doi.org\/10.1038\/s41467-020-18777-y<\/h5>\n
Abstract<\/h2>\n
\n
Mycoplasma pneumoniae<\/i>\u00a0is a bacterial human pathogen that causes primary atypical pneumonia.\u00a0M. pneumoniae<\/i>\u00a0motility and infectivity are mediated by the immunodominant proteins P1 and P40\/P90, which form a transmembrane adhesion complex. Here we report the structure of P1, determined by X-ray crystallography and cryo-electron microscopy, and the X-ray structure of P40\/P90. Contrary to what had been suggested, the binding site for sialic acid was found in P40\/P90 and not in P1. Genetic and clinical variability concentrates on the N-terminal domain surfaces of P1 and P40\/P90. Polyclonal antibodies generated against the mostly conserved C-terminal domain of P1 inhibited adhesion of\u00a0M. pneumoniae<\/i>, and serology assays with sera from infected patients were positive when tested against this C-terminal domain. P40\/P90 also showed strong reactivity against human infected sera. The architectural elements determined for P1 and P40\/P90 open new possibilities in vaccine development against\u00a0M. pneumoniae<\/i>\u00a0infections.<\/p>\n<\/div>\n<\/div>\n<\/section>\n
\n
\n
\u00a0<\/h2>\n<\/div>\n<\/section>\n","protected":false},"excerpt":{"rendered":"
https:\/\/www.nature.com\/articles\/s41467-020-18777-y Vizarraga, D., Kawamoto, A., Matsumoto, U.\u00a0et al.\u00a0Immunodominant proteins P1 and P40\/P90 from human pathogen\u00a0Mycoplasma pneumoniae.\u00a0Nat Commun\u00a011,\u00a05188 (2020). https:\/\/doi.org\/10.1038\/s41467-020-18777-y Abstract Mycoplasma pneumoniae\u00a0is a bacterial human pathogen that causes primary atypical pneumonia.\u00a0M. pneumoniae\u00a0motility and infectivity are mediated by the immunodominant proteins P1 and P40\/P90, which form a transmembrane adhesion complex. Here we report the structure of […]<\/p>\n","protected":false},"author":65,"featured_media":2492,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[4],"tags":[],"_links":{"self":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/3618"}],"collection":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/users\/65"}],"replies":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/comments?post=3618"}],"version-history":[{"count":1,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/3618\/revisions"}],"predecessor-version":[{"id":3620,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/3618\/revisions\/3620"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/media\/2492"}],"wp:attachment":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/media?parent=3618"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/categories?post=3618"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/tags?post=3618"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}