{"id":2459,"date":"2019-07-24T12:49:51","date_gmt":"2019-07-24T11:49:51","guid":{"rendered":"https:\/\/ibb.uab.cat\/?p=2459"},"modified":"2019-07-24T13:21:30","modified_gmt":"2019-07-24T12:21:30","slug":"dr-a-villaverde-targeting-antitumoral-proteins-to-breast-cancer-by-local-administration-of-functional-inclusion-bodies","status":"publish","type":"post","link":"https:\/\/ibb.uab.cat\/index.php\/2019\/07\/24\/dr-a-villaverde-targeting-antitumoral-proteins-to-breast-cancer-by-local-administration-of-functional-inclusion-bodies\/","title":{"rendered":"Dr. A Villaverde: Targeting Antitumoral Proteins to Breast Cancer by Local Administration of Functional Inclusion Bodies"},"content":{"rendered":"<div class=\"abstract-group\">\n<section id=\"section-1-en\" class=\"article-section article-section__abstract\" lang=\"en\" data-lang=\"en\">\n<h2>https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/advs.201900849<\/h2>\n<p>&nbsp;<\/p>\n<h2 id=\"d2393341\" class=\"article-section__header section__title main abstractlang_en main\"><img loading=\"lazy\" class=\"wp-image-2460  alignleft\" src=\"https:\/\/ibb.uab.cat\/wp-content\/uploads\/advs1261-fig-0001-m.jpg\" alt=\"\" width=\"807\" height=\"501\" srcset=\"https:\/\/ibb.uab.cat\/wp-content\/uploads\/advs1261-fig-0001-m.jpg 1000w, https:\/\/ibb.uab.cat\/wp-content\/uploads\/advs1261-fig-0001-m-300x186.jpg 300w, https:\/\/ibb.uab.cat\/wp-content\/uploads\/advs1261-fig-0001-m-768x477.jpg 768w, https:\/\/ibb.uab.cat\/wp-content\/uploads\/advs1261-fig-0001-m-419x260.jpg 419w\" sizes=\"(max-width: 807px) 100vw, 807px\" \/>Abstract<\/h2>\n<div class=\"article-section__content en main\">\n<p style=\"text-align: justify;\">Two structurally and functionally unrelated proteins, namely Omomyc and p31, are engineered as CD44\u2010targeted inclusion bodies produced in recombinant bacteria. In this unusual particulate form, both types of protein materials selectively penetrate and kill CD44<sup>+<\/sup> tumor cells in culture, and upon local administration, promote destruction of tumoral tissue in orthotropic mouse models of human breast cancer. These findings support the concept of bacterial inclusion bodies as versatile protein materials suitable for application in chronic diseases that, like cancer, can benefit from a local slow release of therapeutic proteins.<\/p>\n<\/div>\n<\/section>\n<\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/advs.201900849 &nbsp; Abstract Two structurally and functionally unrelated proteins, namely Omomyc and p31, are engineered as CD44\u2010targeted inclusion bodies produced in recombinant bacteria. In this unusual particulate form, both types of protein materials selectively penetrate and kill CD44+ tumor cells in culture, and upon local administration, promote destruction of tumoral tissue in orthotropic mouse models [&hellip;]<\/p>\n","protected":false},"author":65,"featured_media":2461,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[4],"tags":[],"_links":{"self":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/2459"}],"collection":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/users\/65"}],"replies":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/comments?post=2459"}],"version-history":[{"count":1,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/2459\/revisions"}],"predecessor-version":[{"id":2462,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/2459\/revisions\/2462"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/media\/2461"}],"wp:attachment":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/media?parent=2459"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/categories?post=2459"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/tags?post=2459"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}