{"id":2013,"date":"2018-11-05T08:43:47","date_gmt":"2018-11-05T07:43:47","guid":{"rendered":"https:\/\/ibb.uab.cat\/?p=2013"},"modified":"2018-11-05T09:00:06","modified_gmt":"2018-11-05T08:00:06","slug":"dr-a-villaverde-assembly-of-histidine-rich-protein-materials-controlled-through-divalent-cations","status":"publish","type":"post","link":"https:\/\/ibb.uab.cat\/index.php\/2018\/11\/05\/dr-a-villaverde-assembly-of-histidine-rich-protein-materials-controlled-through-divalent-cations\/","title":{"rendered":"Dr. A. Villaverde: Assembly of histidine-rich protein materials controlled through divalent cations"},"content":{"rendered":"<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1742706118306299\" target=\"_blank\" rel=\"noopener\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1742706118306299<\/a><\/p>\n<h2 class=\"section-title\">Abstract<\/h2>\n<div id=\"as010\">\n<p id=\"sp0010\">Nanostructured protein materials show exciting biomedical applications, since both structure and function can be genetically programmed. In particular, self-assembling histidine-rich proteins benefit from functional <a title=\"Learn more about Plasticity\" href=\"https:\/\/www.sciencedirect.com\/topics\/materials-science\/plasticity\">plasticity<\/a> that allows the generation of protein-only <a title=\"Learn more about Nanoparticles\" href=\"https:\/\/www.sciencedirect.com\/topics\/chemical-engineering\/nanoparticles\">nanoparticles<\/a> for cell targeted drug delivery. However, the rational development of constructs with improved functions is limited by a poor control of the <a title=\"Learn more about Oligomerization\" href=\"https:\/\/www.sciencedirect.com\/topics\/materials-science\/oligomerization\">oligomerization<\/a> process. By exploring cross-interactions between histidine-tagged building blocks, we have identified a critical architectonic role of divalent cations. The obtained data instruct about how histidine-rich protein materials can be assembled, disassembled and reassembled within the nanoscale through the stoichiometric manipulation of divalent ions, in a biochemical approach to <a title=\"Learn more about Biomaterials Design\" href=\"https:\/\/www.sciencedirect.com\/topics\/materials-science\/biomaterials-design\">biomaterials design<\/a>.<\/p>\n<\/div>\n<h2 class=\"section-title\">Graphical abstract<\/h2>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" class=\" wp-image-2014 alignleft\" src=\"https:\/\/ibb.uab.cat\/wp-content\/uploads\/1-s2.0-S1742706118306299-ga1.jpg\" alt=\"\" width=\"538\" height=\"210\" srcset=\"https:\/\/ibb.uab.cat\/wp-content\/uploads\/1-s2.0-S1742706118306299-ga1.jpg 500w, https:\/\/ibb.uab.cat\/wp-content\/uploads\/1-s2.0-S1742706118306299-ga1-300x117.jpg 300w\" sizes=\"(max-width: 538px) 100vw, 538px\" \/><\/p>\n<div id=\"ab010\" class=\"abstract author\" lang=\"en\">\n<div id=\"as010\" style=\"text-align: justify;\">\n<p id=\"sp0010\" style=\"text-align: justify;\">\u00a0<\/p>\n<\/div>\n<div id=\"as015\">\n<h3 id=\"st015\" style=\"text-align: justify;\">Statement of Significance<\/h3>\n<p id=\"sp0015\" style=\"text-align: justify;\">Divalent metal and non-metal cations such as Ni<sup>2+<\/sup>, Cu<sup>2+<\/sup> Ca<sup>2+<\/sup> and Zn<sup>2+<\/sup> have been identified as unexpected molecular tools to control the assembling, disassembling and reassembling of histidine-rich protein materials at the nanoscale. Their stoichiometric manipulation allows generating defined protein-protein cross-molecular contacts between building blocks, for a powerful nano-biochemical manipulation of the material\u2019s architecture.<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1742706118306299 Abstract Nanostructured protein materials show exciting biomedical applications, since both structure and function can be genetically programmed. In particular, self-assembling histidine-rich proteins benefit from functional plasticity that allows the generation of protein-only nanoparticles for cell targeted drug delivery. However, the rational development of constructs with improved functions is limited by a poor control of [&hellip;]<\/p>\n","protected":false},"author":65,"featured_media":2015,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[4],"tags":[],"_links":{"self":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/2013"}],"collection":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/users\/65"}],"replies":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/comments?post=2013"}],"version-history":[{"count":1,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/2013\/revisions"}],"predecessor-version":[{"id":2016,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/2013\/revisions\/2016"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/media\/2015"}],"wp:attachment":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/media?parent=2013"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/categories?post=2013"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/tags?post=2013"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}