{"id":1579,"date":"2018-06-24T21:59:19","date_gmt":"2018-06-24T20:59:19","guid":{"rendered":"http:\/\/ibb.uab.cat\/?p=1579"},"modified":"2018-06-24T22:00:34","modified_gmt":"2018-06-24T21:00:34","slug":"1579","status":"publish","type":"post","link":"https:\/\/ibb.uab.cat\/index.php\/2018\/06\/24\/1579\/","title":{"rendered":"Selective CXCR4+ Cancer Cell Targeting and Potent Antineoplastic Effect by a Nanostructured Version of Recombinant Ricin"},"content":{"rendered":"<p style=\"text-align: justify;\">\u00a0<\/p>\n<nav class=\"stickybar coolBar trans coolBar--res fixed-element\">\n<div class=\"stickybar__wrapper coolBar__wrapper clearfix\">\n<div class=\"coolBar__second rlist\">\n<div class=\"relative\">\n<div id=\"share_Pop\" class=\"share__block dropBlock__holder fixed\" role=\"menu\" data-db-target-of=\"dff42abe-4b17-4fe9-a9c5-625405cd1007\" aria-labelledby=\"share__ctrl\">\n<div class=\"atclear\"><img loading=\"lazy\" class=\"wp-image-1580 alignleft\" src=\"http:\/\/ibb.uab.cat\/wp-content\/uploads\/articulo3villaverde.jpg\" alt=\"\" width=\"424\" height=\"381\" srcset=\"https:\/\/ibb.uab.cat\/wp-content\/uploads\/articulo3villaverde.jpg 1364w, https:\/\/ibb.uab.cat\/wp-content\/uploads\/articulo3villaverde-300x269.jpg 300w, https:\/\/ibb.uab.cat\/wp-content\/uploads\/articulo3villaverde-768x690.jpg 768w, https:\/\/ibb.uab.cat\/wp-content\/uploads\/articulo3villaverde-1024x920.jpg 1024w, https:\/\/ibb.uab.cat\/wp-content\/uploads\/articulo3villaverde-290x260.jpg 290w\" sizes=\"(max-width: 424px) 100vw, 424px\" \/><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/nav>\n<div class=\"article__body\" style=\"text-align: justify;\">\n<div class=\"abstract-group\">\n<section id=\"section-1-en\" class=\"article-section article-section__abstract\" lang=\"en\" data-lang=\"en\">\n<h3 class=\"article-section__header main abstractlang_en main\">Abstract<\/h3>\n<div class=\"article-section__content en main\">\n<p>Under the unmet need of efficient tumor\u2010targeting drugs for oncology, a recombinant version of the plant toxin ricin (the modular protein T22\u2010mRTA\u2010H6) is engineered to self\u2010assemble as protein\u2010only, CXCR4\u2010targeted nanoparticles. The soluble version of the construct self\u2010organizes as regular 11 nm planar entities that are highly cytotoxic in cultured CXCR4<sup>+<\/sup>\u00a0cancer cells upon short time exposure, with a determined IC50 in the nanomolar order of magnitude. The chemical inhibition of CXCR4 binding sites in exposed cells results in a dramatic reduction of the cytotoxic potency, proving the receptor\u2010dependent mechanism of cytotoxicity. The insoluble version of T22\u2010mRTA\u2010H6 is, contrarily, moderately active, indicating that free, nanostructured protein is the optimal drug form. In animal models of acute myeloid leukemia, T22\u2010mRTA\u2010H6 nanoparticles show an impressive and highly selective therapeutic effect, dramatically reducing the leukemia cells affectation of clinically relevant organs. Functionalized T22\u2010mRTA\u2010H6 nanoparticles are then promising prototypes of chemically homogeneous, highly potent antitumor nanostructured toxins for precise oncotherapies based on self\u2010mediated intracellular drug delivery.<\/p>\n<\/div>\n<\/section>\n<\/div>\n<\/div>\n<p style=\"text-align: justify;\">\u00a0<\/p>\n<p style=\"text-align: justify;\">\u00a0<\/p>\n<p style=\"text-align: justify;\"><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/smll.201800665\" target=\"_blank\" rel=\"noopener\">https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/smll.201800665<\/a><\/p>\n<p style=\"text-align: justify;\">\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u00a0 Abstract Under the unmet need of efficient tumor\u2010targeting drugs for oncology, a recombinant version of the plant toxin ricin (the modular protein T22\u2010mRTA\u2010H6) is engineered to self\u2010assemble as protein\u2010only, CXCR4\u2010targeted nanoparticles. The soluble version of the construct self\u2010organizes as regular 11 nm planar entities that are highly cytotoxic in cultured CXCR4+\u00a0cancer cells upon short [&hellip;]<\/p>\n","protected":false},"author":65,"featured_media":1580,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[4],"tags":[],"_links":{"self":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/1579"}],"collection":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/users\/65"}],"replies":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/comments?post=1579"}],"version-history":[{"count":3,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/1579\/revisions"}],"predecessor-version":[{"id":1583,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/1579\/revisions\/1583"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/media\/1580"}],"wp:attachment":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/media?parent=1579"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/categories?post=1579"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/tags?post=1579"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}