News

Salvador Ventura, director de l’Institut de Biotecnologia i de Biomedicina, pronunciarà la ponència “Desmuntant el LEGO: A la cerca d'una cura per les malalties neurodegeneratives".El 22 de novembre l’Hotel Exe Campus acollirà el lliurament dels títols i premis extraordinaris del doctorat.  A l’acte, que s’iniciarà a les 18 hores, Victòria Nogués, secretària acadèmica de l’Escola de Doctorat, presentarà l’acte que comptarà també amb les intervencions institucionals de Margarita Arboix, rectora de la UAB; Sara Moreno, vicerectora d’Alumnat i Ocupabilitat de la UAB; Armand Sánchez, director de l’Escola de Doctorat i vicerector de Recerca i de Transferència de la UAB; i Tirso Gràcia, membre del Consell Social de la UAB. A més, en representació dels doctors i doctores que reben els seus t

A l'edició 2018, dedicada al càncer, s'hi van presentar 192 projectes, que van ser avaluats per 149 científics d'àmbit internacional especialistes en aquesta matèria en funció de la seva qualitat, metodologia i rellevància. La gestió de l'avaluació la va dur a terme l'Agència de Qualitat i Avaluació Sanitàries de Catalunya, del Departament de Salut. D'acord amb la proposta de la Comissió Assessora Científica de la Fundació La Marató de TV3, el Patronat va acordar distribuir 13.149.870,76 € entre els 43 projectes de recerca científica d'excel·lència següents:   Nanomedicines humanitzades selectivament dirigides a matar les cèl·lules tumorals CXCR4+ per al tractament de la leucèmia mieloide aguda. Dr. Antonio Villaverde Corrales “Selectively humanized nanomedicines aimed at killing CXCR

    Abstract Cell‐selective targeting is expected to enhance effectiveness and minimize side effects of cytotoxic agents. Functionalization of drugs or drug nanoconjugates with specific cell ligands allows receptor‐mediated selective cell delivery. However, it is unclear whether the incorporation of an efficient ligand into a drug vehicle is sufficient to ensure proper biodistribution upon systemic administration, and also at which extent biophysical properties of the vehicle may contribute to the accumulation in target tissues during active targeting. To approach this issue, structural robustness of self‐assembling, protein‐only nanoparticles targeted to the tumoral marker CXCR4 is compromised by reducing the number of histidine residues (from six to five) in a histidine‐based

El projecte Micro-Mundo està integrat en la xarxa Micro-Mundo de la Societat Espanyola de Microbiologia que a la vegada és soci de Tinny Earth® de la Universitat de Wisconsin. Mitjançant una estratègia d’aprenentatge i servei, els estudiants de grau de la UAB, supervisats per professors de Microbiologia de la UAB, lideren una experiència pràctica per la qual els estudiants de secundària s’enfronten a un projecte de recerca real. Les activitats es realitzen a les seves escoles amb l'objectiu d'obtenir una col·lecció de bacteris possibles productors d’antibiòtics que es posa a l’abast de tota la comunitat científica. A la UAB aquest programa el lidera i coordina la Dra. Montserrat Llagostera de la Unitat de Microbiologia Campus del Departament de Genètica i de Microbiologia i al IBB par

  ACS Biomater. Sci. Eng.2019 https://pubs.acs.org/doi/abs/10.1021/acsbiomaterials.9b01085   Abstract Eighty areas with different structural and compositional characteristics made of bacterial inclusion bodies formed by the fibroblast growth factor (FGF-IBs) were simultaneously patterned on a glass surface with an evaporation-assisted method that relies on the coffee-drop effect. The resulting surface patterned with these protein nanoparticles enabled to perform a high-throughput study of the motility of NIH-3T3 fibroblasts under different conditions including the gradient steepness, particle concentrations, and area widths of patterned FGF-IBs, using for the data analysis a methodology that includes “heat maps”. From this analysis, we observed that gradients of concentr

Un projecte de la UAB per avançar en la cerca d'una teràpia efectiva contra el pàrkinson ha estat seleccionat per la plataforma Precipita per buscar finançament a través del micromecenatge. El finançament permetrà aprofundir en l'estudi de la molècula SynuClean-D, que ja s'ha mostrat eficaç per detenir i revertir la neurodegeneració que provoca la malaltia en cultius cel·lulars i en un model animal simple.   El projecte per al desenvolupament de SynuClean-D com a molècula terapèutica per al tractament de la malaltia de Parkinson està liderat per Salvador Ventura, investigador de l'Institut de Biotecnologia i Biomedicina (IBB) i del Departament de Bioquímica i Biologia Molecular de la Universitat Autònoma de Barcelona (UAB).   La malaltia de Parkinson afecta més de 7 milions de per

SCIENCE CHINA Materials Published online 19 September 2019 | https://doi.org/10.1007/s40843-019-9582-9 http://engine.scichina.com/publisher/scp/journal/SCMs/doi/10.1007/s40843-019-9582-9?slug=fulltext   Abstract Modular protein engineering is suited to recruit complex and multiple functionalities in single-chain polypeptides. Although still unexplored in a systematic way, it is anticipated that the positioning of functional domains would impact and refine these activities, including the ability to organize as supramolecular entities and to generate multifunctional protein materials. To explore this concept, we have repositioned functional segments in the modular protein T22-GFP-H6 and characterized the resulting alternative fusions. In T22-GFP-H6, the combination of T22 and H6

Nature Communications 10,  Article number: 4222 (2019)   https://www.nature.com/articles/s41467-019-12173-x.epdf?author_access_token=cVjT1p3din4tGJbNLDyel9RgN0jAjWel9jnR3ZoTv0P-2IqhjSjJ3h8OoQACdg3_2Zs57EgxdseDbCAlUgZO9jSYZMidnZsRJxkAkaIfu2LAxppiY3VN8K2eAt2G6O7iHH_N5qqpM4UMjovqEWHu9A%3D%3D Open Access Abstract Inversions are one type of structural variants linked to phenotypic differences and adaptationin multiple organisms. However, there is still very little information about polymorphicinversions in the human genome due to the difficulty of their detection. Here, we develop anew high-throughput genotyping method based on probe hybridization and amplification, andwe perform a complete study of 45 common human inversions of 0.1–415 kb. Most inversionspromoted by homologous reco

https://www.future-science.com/doi/abs/10.4155/fmc-2019-0015 https://doi.org/10.4155/fmc-2019-0015   Aim:Stenotrophomonas maltophilia (Sm) and Burkholderia cepacia complex (BCC) are Gram-negative bacterial pathogens, which are typically multidrug resistant and excellent biofilm producers. These phenotypes are controlled by quorum sensing (QS) systems from the diffusible signal factor (DSF) family. We aim to interfere with this QS system as an alternative approach in combatting such difficult-to-treat infections. Materials & methods: A library of sulfonamide-based DSF bioisosteres was synthesized and tested against the major phenotypes regulated by QS. Results & conclusion: Several analogs display significant antibiofilm activity while the majority increase the action of the...

https://onlinelibrary.wiley.com/doi/full/10.1002/chem.201902796 https://doi.org/10.1002/chem.201902796 Abstract An inorganic sandwich molecule, Na[Co(C2B9H11)2], able to produce vesicles through self‐assembly and known to produce strong dihydrogen‐bond interactions with amine groups is capable of interacting with proteins. This dual non‐bonding ability of Na[Co(C2B9H11)2] is what makes this molecule unique: it can be firmly anchored to a protein surface and is capable of extending over it. To prove this, the widely available bovine serum albumin (BSA), which has many pendant amino groups in its structure, has been taken as the model protein. It has been found that around 100 molecules of Na[Co(C2B9H11)2] preserve the native structure of BSA, while endorsing it with a significantly inc