IBB UAB

Author: Nati Infante

Dr. Salvador Ventura “A single cysteine posttranslational oxidation suffices to compromise globular proteins kinetic stability and promote amyloid formation”

Dr. Salvador Ventura “A single cysteine posttranslational oxidation suffices to compromise globular proteins kinetic stability and promote amyloid formation”

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Abstract Oxidatively modified forms of proteins accumulate during aging. Oxidized protein conformers might act as intermediates in the formation of amyloids in age-related disorders. However, it is not known whether this amyloidogenic conversion requires an extensive protein oxidative damage or it can be promoted just by a discrete, localized post-translational modification of certain residues. Here, we demonstrate that the irreversible oxidation of a single free Cyssuffices to severely perturb the folding energy landscape of a stable globular protein, compromise its kinetic stability, and lead to the formation of amyloids under physiological conditions. Experiments and simulations converge to indicate that this specific oxidation-promoted protein aggregation requires only local unfol
Dr. A. Villaverde: Intracellular trafficking of a dynein-based nanoparticle designed for gene delivery

Dr. A. Villaverde: Intracellular trafficking of a dynein-based nanoparticle designed for gene delivery

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Abstract The success of viruses in the delivery of the viral genome to target cells relies on the evolutionary selection of protein-based domains able to hijack the intermolecular interactions through which cells respond to intra- and extracellular stimuli. In an effort to mimic viral infection capabilities during non-viral gene delivery, a modular recombinant protein named T-Rp3 was recently developed, containing a DNA binding domain, a dynein molecular motor interacting domain, and a TAT-derived transduction domain. Here, we analyzed at the microscopic level the mechanisms behind the cell internalization and intracellular trafficking of this highly efficient modular protein vector. We found that the protein has the ability to self-assemble in discrete protein nanoparticles resemblin...
Engineering multifunctional protein nanoparticles by in vitro disassembling and reassembling of heterologous building blocks

Engineering multifunctional protein nanoparticles by in vitro disassembling and reassembling of heterologous building blocks

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Engineering multifunctional protein nanoparticles by in vitro disassembling and reassembling of heterologous building blocks Ugutz Unzueta1, Naroa Serna2, Laura Sánchez-García3, Mónica Roldan4, Alejandro Sánchez-Chardi5, Ramon Mangues6, Antonio Villaverde Villaverde7 and Esther Vázquez8   http://iopscience.iop.org/article/10.1088/1361-6528/aa963e#top
Totes les universitats donen suport a la comissió de mediació, diàleg i conciliació

Totes les universitats donen suport a la comissió de mediació, diàleg i conciliació

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El 4 d'octubre, entitats de la societat civil catalana, amb la participació de la UAB i la UB, van constituir una Comissió Independent per a la mediació, el diàleg i la conciliació. Ara, totes les universitats catalanes han donat suport a aquesta iniciativa. Totes les universitats catalanes donem suport a la iniciativa de creació d'una comissió independent de mediació, diàleg i conciliació promoguda pel Col·legi de l'Advocacia de Barcelona i altres entitats de la societat civil. Universitat de Barcelona, Universitat Autònoma de Barcelona, Universitat Politècnica de Catalunya, Universitat Pompeu Fabra, Universitat de Lleida, Universitat de Girona, Universitat Rovira i Virgili, Universitat Ramon Llull, Universitat Oberta de Catalunya, Universitat de Vic - Universitat Central de Catalunya

TESI: M. Carmen García (Sala de Graus – Facultat de Medicina) 11:30h

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Carcterización estructural y funcional de dos metalocarboxipeptidasas de la familia M14 con especificidad de sustrato tipo acídico: carboxipeptidasa citosólica 6 y carboxipeptidasa O humanas   Directors: Francesc Xavier Avilés Puigvert, Javier García Pardo, Julia Lorenzo Rivera   Dia i hora: Divendres 29, Setembre de 2017 - 11:30h Lloc: Sala de Graus - Facultat de Medicina