IBB UAB

Author: Nati Infante

Protein Folding and Conformational Diseases: “The small aromatic compound SynuClean-D inhibits the aggregation and seeded polymerization of multiple α-synuclein strains”

Protein Folding and Conformational Diseases: “The small aromatic compound SynuClean-D inhibits the aggregation and seeded polymerization of multiple α-synuclein strains”

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Available online 4 April 2022, 101902 https://doi.org/10.1016/j.jbc.2022.101902 Abstract Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, as well as the accumulation of intra-neuronal proteinaceous inclusions known as Lewy bodies and Lewy neurites. The major protein component of Lewy inclusions is the intrinsically disordered protein α-Synuclein (α-Syn), which can adopt diverse amyloid structures. Different conformational strains of α-Syn have been proposed to be related to the onset of distinct synucleinopathies; however, how specific amyloid fibrils cause distinctive pathological traits is not clear. Here, we generated three different α-Syn amyloid conformations at differe
Nanobiotechnology: “All-in-one biofabrication and loading of recombinant vaults in human cells”

Nanobiotechnology: “All-in-one biofabrication and loading of recombinant vaults in human cells”

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Biofabrication, Volume 14, Number 2 https://iopscience.iop.org/journal/1758-5090 Abstract One of the most promising approaches in the drug delivery field is the use of naturally occurring self-assembling protein nanoparticles, such as virus-like particles, bacterial microcompartments or vault ribonucleoprotein particles as drug delivery systems (DDSs). Among them, eukaryotic vaults show a promising future due to their structural features, in vitro stability and non-immunogenicity. Recombinant vaults are routinely produced in insect cells and purified through several ultracentrifugations, both tedious and time-consuming processes. As an alternative, this work proposes a new approach and protocols for the production of recombinant vaults in human cells by transient gene...

SEMINARIS: “Role of Stem Cells in Regenerative Medicine and Cancer Biology”PhD THAMIL SELVEE RAMASAMY. 12:30 h.

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We will be receiving an international visit at the IBB, under an Erasmus+ mobility grant, from Thamil Selvee, Head of the Stem Cell Biology Laboratory at the Universiti Malaya in Malaysia. You can also have a look at her full CV here. She will be hosted by Esther Vázquez. The visit at the IBB and other institutions will take place during the 4th-8th of April 2022.  Benefiting from the occasion, Thamil will give us all a seminar at the Aula IBB on April 6th 12.30 pm on the topic: Role of Stem Cells in Regenerative Medicine and Cancer Biology.
Yeast Molecular Biology: “The toxic effects of yeast Ppz1 phosphatase are counteracted by subcellular relocalization mediated by its regulatory subunit Hal3”

Yeast Molecular Biology: “The toxic effects of yeast Ppz1 phosphatase are counteracted by subcellular relocalization mediated by its regulatory subunit Hal3”

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Marcel Albacar,Diego Velázquez,Antonio Casamayor,Joaquín Ariño https://doi.org/10.1002/1873-3468.14330 Abstract Overexpression of Saccharomyces cerevisiae protein phosphatase Ppz1 strongly impairs cell growth. Ppz1 is negatively regulated by its subunit Hal3, and Hal3 overexpression fully counteracts the toxic effects derived from high levels of the phosphatase. We show that Ppz1 localizes at the plasma membrane, and that co-expression of Hal3 recruits Ppz1 to internal membranes (mostly vacuolar). This effect is not observed in a catalytically impaired mutant of Ppz1. Disruption of intracellular trafficking by deletion of the ESCRT-0 component VPS27 abolishes both Hal3-mediated relocalization of Ppz1 and normalization of cell growth, without affecting Ppz1
Bacterial Molecular Genetics: “Strain-specific interspecies interactions between co-isolated pairs of Staphylococcus aureus and Pseudomonas aeruginosa from patients with tracheobronchitis or bronchial colonization”

Bacterial Molecular Genetics: “Strain-specific interspecies interactions between co-isolated pairs of Staphylococcus aureus and Pseudomonas aeruginosa from patients with tracheobronchitis or bronchial colonization”

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Scientific Reports volume 12, Article number: 3374 (2022) https://www.nature.com/articles/s41598-022-07018-5 Abstract Dual species interactions in co-isolated pairs of Staphylococcus aureus and Pseudomonas aeruginosa from patients with tracheobronchitis or bronchial colonization were examined. The genetic and phenotypic diversity between the isolates was high making the interactions detected strain-specific. Despite this, and the clinical origin of the strains, some interactions were common between some co-isolated pairs. For most pairs, P. aeruginosa exoproducts affected biofilm formation and reduced growth in vitro in its S. aureus counterpart. Conversely, S. aureus did not impair biofilm formation and stimulated swarming motility in P. aeruginosa. Co-culture in a m
Noves troballes sobre els particulars cromosomes sexuals dels marsupials

Noves troballes sobre els particulars cromosomes sexuals dels marsupials

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Un estudi liderat per investigadores de la UAB (IBB) aporta noves dades sobre el comportament dels cromosomes sexuals en les cèl·lules precursores dels espermatozoides dels marsupials, inclòs un mecanisme relacionat amb l’allargament dels telòmers inèdit fins ara en els cromosomes d'altres mamífers. Els resultats de l'estudi, publicat a PLOS Genetics, suposen un avanç en el coneixement de la funció de l'organització del genoma de les espècies. Un equip de recerca internacional liderat per la UAB ha descrit nous mecanismes que regulen la formació d'espermatozoides en diverses espècies de marsupials i que difereixen dels descrits prèviament en altres mamífers, com l'ésser humà i el ratolí. L'estudi, publicat a la revista PLoS Genetics, ha estat dirigit per Aurora Ruiz-Herrera, in