IBB UAB

Ignasi Roig Navarro

Personal information

Email: ignasi.roig@uab.cat

Unit: Genomics in Evolution and Disease

Group: Genome Integrity and Instability

Category: Professor Lector

Lab phone: 935811379

Academic information and publications

Research:

 

Education:
1999 B.S. Biology, Universitat Autònoma de Barcelona, Barcelona, Spain
2002 Master in Cell Biology, Universitat Autònoma de Barcelona, Barcelona, Spain
2005 Ph.D. Cell Biology, Universitat Autònoma de Barcelona, Barcelona, Spain
 
Positions and Appointments:
09/98-07/99 Undergraduate student at the Cell Biology, Physiology and Immunology Department, UAB.
09/99-02/01 Associate professor at the Cell Biology, Physiology and Immunology Department, UAB, Spain.
06/03-08/03 Postgraduate Researcher at Dr. Ashley Lab, Yale University, New Haven, USA.
07/05-12/05 Postdoctoral Fellow at the Cell Biology, Physiology and Immunology Department, UAB, Spain.
02/06-07/08 Postdoctoral Fellow, Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, USA.
08/08-01/10 Research Fellow, Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, USA.
09/09-present Lecturer, Cytology and Histology Unit, Dept. Cell Biology, Physiology & Immunology Universitat Autònoma de Barcelona.
 
Honors and Awards:
2001-2005 Predoctoral fellowship from the Spanish Government (Ministerio de Educación y Cultura, programa de Formación de Profesorado Universitario).
2001-2003 Predoctoral travel fellowships Spanish Government (Ministerio de Educación y Cultura, programa de Formación de Profesorado Universitario):
- Host institution: Free University of Brussels, Belgium, 9-12/2001.
- Host institution: Max Planck Institute for Molecular Genetics, Germany, 8-10/2002.
- Host institution: Yale University, USA, 7-8/2003.
2005 Ph.D., Excellent cum laude, Universitat Autònoma de Barcelona.
2005 Extraordinary award for the best defended thesis of the Department of Cell Biology, Physiology and Immunology of the Universitat Autònoma from Barcelona.
2005,2006 Nominee to the 7th and 8th Royan International Research Award on Reproductive Biomedicine & Stems Cells, Teheran, Iran.
2008 “Professor Lector” Acreditation, Agència de la Qualitat Universitària (AQU), Spain.
2008,2009 Invited professor, Cell Biology PhD program, Universitat Autònoma de Barcelona, Spain.
2009 Beatriu de Pinós Fellowship, Generalitat de Catalunya, Spain.
2010 Short term travel fellowship, European Molecular Biology Organization (EMBO), Germany.
2010 Research visit fellowship BE-DGR, AGAUR-Generalitat de Catalunya. Host Institute: Memorial Sloan-Kettering Cancer Center, USA, 7-8/2010
2011 Ramón y Cajal fellowship, Ministerio Ciencia e Innovación, Spain. (Awarded-Declined). 
2011 Young Investigator Award, Aposta program, Universitat Autònoma de Barcelona, Spain.
2012 "Profesor Titular" Acreditation, ANECA, Spain

 (For more information please visit http://grupsderecerca.uab.cat/roiglab/en)

 


Publications

1. Garrabou G., Roig I., Saavedra D., Fernández-Moran J., Ponsa M. Estudios citogenéticos en la población de nutria euroasiática (Lutra lutra reintroducida en el Parc Natural dels Aiguamolls de l’Empordà y comparación cariotípica con otros mustélidos. Galemys 2003 15:115-124.

2. Roig I., Vanrell I., Ortega A., Cabero Ll., Egozcue E., Garcia M. The use of foetal ovarian stromal cell culture for cytogenetic diagnosis. Cytotechnology 2003 41:45-49.

3. Roig, I.*, Liebe, B.*, Egozcue, J., Cabero, Ll., Garcia, M. and Scherthan, H. Female-specific features of recombinational double-stranded DNA repair in relation to synapsis and telomere dynamics in human oocytes. Chromosoma 2004 113: 22-33. (* Co-first authors).

4. Roig I., Robles P., Garcia R., Egozcue J., Liebe B., Scherthan H, Garcia M. Chromosome 18 pairing behavior in human trisomic oocytes. Presence of an extra chromosome extends bouquet stage. Reproduction 2005 129: 565-575.

5. Roig I, Robles P., Garcia R., Martin M., Egozcue J., Cabero Ll., Barambio S., Garcia M. Evolution of the meiotic prophase and of the chromosome pairing process during human fetal ovarian development. Human Reproduction 2005 20:2463-9.

6. Roig I., Garcia R., Robles P., Cortvrindt R., Egozcue J., Smitz J., Garcia M. Human fetal ovarian culture permits meiotic progression and chromosome-pairing process Human Reproduction. 2006 6:1359-67.

7. Robles P.*, Roig I.*, Garcia R., Ortega A., Egozcue J., Cabero Ll. and Garcia M. Pairing and Synapsis in oocytes from female fetuses with euploid and aneuploid chromosome complements. Reproduction 2007 133:899-907. (* Co-first authors).

8. Barchi M.*, Roig I.*, Di Giacommo M., de Roiij DG., Keeney S. and Jasin M. ATM promotes the obligate XY crossover and both crossover control and chromosome axis integrity on autosomes. PLoS Genet. 2008 May 23;4(5):e1000076. (* Co-first authors).

9. Roig I., Keeney S. Probing meiotic recombination decisions. Dev Cell. 2008 Sep;15(3):331-2.

10. Garcia-Cruz R., Roig I. and Garcia-Caldes M. Maternal origin of the human aneuploidies. Are homologue synapsis and recombination to blame? Notes (learned) from the underbelly. Genome Dyn. 2009; 5:128-36.

11. Garcia-Cruz R., Roig I., Robles P., Scherthan H. and Garcia Caldes M. ATR implication in DSB signaling and in the pachytene checkpoint in human oocytes. Reprod Biomed Online. 2009 Jan;18(1):37-44.

12. Robles P., Roig I., Garcia R., Brieño M., Martin M., Barbero J.L., Cabero Ll. and Garcia Caldes M. Analysis of the recombination process along chromosome 21 during human female pachytene stage. Reprod BioMed Online 2009 Jun;18(6):784-94. .

13. Wojtasz L., Daniel K., Roig I., Bolcun-Filas E., Xu H., Boonsanay V., Eckmann C., Cooke H.J., Jasin M., Keeney S., McKay M.J. and Toth A. Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase. PLoS Genet. 2009 Oct;5(10):e1000702.

14. Garcia-Cruz R, Casanovas A, Brieño-Enríquez M, Robles P, Roig I, Pujol A, Cabero L, Durban M, Garcia Caldés M. Cytogenetic analyses of human oocytes provide new data on non-disjunction mechanisms and the origin of trisomy 16. Hum Reprod. 2010 Jan;25(1):179-91.

15. Brieño-Enríquez MA, Robles P, García-Cruz R, Roig I, Cabero L, Martínez F, Garcia Caldés M. A new culture technique that allows in vitro meiotic prophase development of fetal human oocytes. Hum Reprod. 2010 Jan;25(1):74-84.

16. Lu WJ, Chapo J, Roig I, Abrams JM. Meiotic recombination provokes functional activation of the p53 regulatory network. Science. 2010 Jun 4;328(5983):1278-81.

17. Garcia-Cruz R, Brieño MA, Roig I, Grossmann M, Velilla E, Pujol A, Cabero L, Pessarrodona A, Barbero JL, Caldés MG. Dynamics of cohesin proteins REC8, STAG3, SMC1 beta and SMC3 are consistent with a role in sister chromatid cohesion during meiosis in human oocytes. Hum Reprod. 2010 Sep;25(9):2316-27.

18. Roig I, Dowdle JA, Toth A, de Rooij DG, Jasin M, Keeney S. Mouse TRIP13/PCH2 is required for recombination and normal higher-order chromosome structure during meiosis. PLoS Genet. 2010 Aug 12;6(8). pii: e1001062.

19. Roig I, Brieño-Enríquez MA, Garcia Caldés M. Meiosis in a bottle: New approaches to overcome mammalian meiocyte study limitations. Genes. 2011, 2(1): 152-168. 

20. Daniel K, Lange J, Hached K, Fu J, Anastassiadis K, Roig I, Steward AF, Wassmann K, Jasin M, Keeney S, Toth A. Meiotic homologue alignment and its quality check are controlled by mouse Hormad1. Nature Cell Biology. [Epub ahead of print] doi:10.1038/ncb2213.

21. Yin Y, Lin C, Tae Kim S, Roig I, Chen H, Liu L, Veith GM, Jin RU, Keeney S, Jasin M, Moley K, Zhou P, Ma L. The E3 ubiquitin ligase cullin 4A regulates meiotic progression in mouse spermatogenesis. Dev Biol. 2011 May 23 [Epub ahead of print] doi:10.1016/j.ydbio.2011.05.661.  

22. Brieño-Enríquez MA, Robles P, Camats-Tarruella N, Garcia-Cruz R, Roig I, Cabero L, Martínez F, Garcia Caldés M. Human meiotic progression and recombination are affected by Bisphenol A exposure during in vitro human oocyte development. Human Reprod. In press.

23. Churchman ML, Roig I, Keeney S, Jasin M, Sherr CJ. Transient Arf expression in spermatogonia prevents p53-dependent elimination of spermatocytes during male germ cell development. PLoS Genet. 7(7): e1002157. doi:10.1371/journal.pgen.1002157.

24. Cole F, Kauppi L., Lange J, Roig I, Wang R, Keeney S, Jasin M. Homeostatic control of recombination is implemented progressively in mouse meiosis. Nature Cell Biology 2012 Mar 4. Doi: 10.1038/ncb2451.